Hi Gentry, I'm on Plaquenil with Arava. I had a lot of problems with Methotrexate as well, but I am not having the same issues with arava (which I was afraid of). The plaquenil worked wonders for me and I took it solo for about 2 years, but after a while I was starting to have a severe flare that wouldn't let up - so we gave it a push with the Arava. i'm doing quite well with the combo. I started last April, i believe.
i'm highly sensitive to a lot of drugs and was initially taking 1 pill twice a day. After a few months some of the side effects were concerning me, so we cut it back to 1 pill a day. I just started toggling my amount in January - 1 pill one day, 2 pills the next. It seems to be helping me through the winter weather better.