Hey Stef.. me again.. ok.. this is what I've found out.. If your friend does get pregnant while on this med, she needs to tell her doc as soon as possible.. the reason why is 'cause in late pregnancy, as with other NSAIDs, Piroxicam or FELDENE should be avoided because it may cause premature closure of the ductus arteriosus.. Ductus arteriosus is a key arterial shunt (ductus) in fetal life. Before birth, blood pumped from the heart through the pulmonary artery toward the lungs is shunted into the aorta. This arterial shunt is a short vessel called the ductus arteriosus. When the shunt is open, it is said to be patent.
The ductus arteriosus usually closes at or shortly after birth, permitting blood from that moment on to course from the heart directly to the lungs. However, if the ductus arteriosus remains open (patent), flow reverses and blood from the aorta is shunted left-to-right into the pulmonary artery and thence recirculated through the lungs.
A PDA may close spontaneously (on its own). If not, it needs to be prompted pharmacologically to close and, if that does not work, it must ligated (tied off) surgically.
PDA is a particularly common problem in premature infants with the respiratory distress syndrome. The left-to-right shunt through the ductus increases their risk of serious complications including brain hemorrhage. IV indomethacin (Indocin) was the conventional therapy to promote closure of PDA in premies but indomethacin affects blood flow to organs such as the kidney and so may lead to complications such as renal failure. Ibuprofen (the active ingredient in Advil, Motrin, Medipren and Nuprin) has been found to work as well as indomethacin in treating PDA in preterm infants with the respiratory distress syndrome and is less likely to impair their kidney function.
The above was taken from this link.. http://www.rxlist.com/cgi/generic/piroxicam_wcp.htm
please pass it on to your friend and tell her we said good luck.. I hope this information is what you needed.. if you need anything else, please let us know.. take good care.. Duck
Moderator of Arthritis Forum
Confirmed Diagnosis of - Psoriatic Arthritis/Spondylitis/Graves Disease/GERD/Scoliosis/Hiatal Hernia/Graves Disease of the Eyes/Chronic UTIs/Migraines/Hypertension
Current Meds - Enbrel/Prilosec/Synthroid/Nitrofurantoin/Midrin/HYZAAR
Past Meds - Inderal/PTU/Prednisone/Voltaren/Feldene/Mobic/Cortisone and Steroid Shots