I don't know a great deal about Humira, but I take Enbrel and I do know that if you have Lupus you are not supposed to use it because it can cause the lupus to become more severe. Like Camama mentioned...plaquenil? It REALLY works, I still take it even now that I am on Enbrel, without it, I still have pain. It helps with pain and fatigue.
Other than the pain and stiffness just the fatigue is the only other thing I can think of at the moment and its much worse without my plaquenil.
Oh boy, I'm sorry to hear how much you are going through and that the plaquenil is not helping. It took a while for it to really kick in for me (But, if it hasn't kicked in after 7 years...I guess you need something else)
I do want to say some of the meds will lower your white blood count. Methotrexate can do a lot of funky things to you. I had pluerisy (however you spell it) while on it. The docs insisted it was not the drug....but I haven't had it since I stopped taking it. Elavil made me very tired and loopy. I'm currently on a plaquenil/Arava mix and it does help quite a bit, I also have to take Nexium as I feel like my chest is going to explode if I don't as well as a slew of vitamins. I was worried about Arava as it is in the same class as methotrexate, but I'm not having the same troubles, thank goodness!
I can say also - if youdon't drink a LOT of water, get LOTS of B vitamin and folic acid in you regularly, the meds can do funky things to you as well. I know this is all little stuff, but combined together, it can make a difference, and anything for the better is a good thing.
I wish you well. hang in there. I hope the docs are able to help get you feeling better VERY soon. ****