Has anyone taken Quinacrine?

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momto3
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Date Joined Nov 2006
Total Posts : 1331
   Posted 9/10/2008 11:13 AM (GMT -7)   
I'm curious if anyone has ever taken this instead of Plaquenil??
 
Thanks in advance!

Ducky
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Date Joined Mar 2005
Total Posts : 3199
   Posted 9/10/2008 1:29 PM (GMT -7)   
If I'm not mistaken, I think some of the people who have Lupus take this.. I personally haven't taken it before.. I'll put a post in the Lupus forum for you, and we'll see what we get.. :)
Moderator of Arthritis Forum
Confirmed Diagnosis of - Psoriatic Arthritis/Spondylitis/Graves Disease/GERD/Scoliosis/Hiatal Hernia/Graves Disease of the Eyes/Chronic UTIs/Migraines/Hypertension
Current Meds -  Enbrel/Prilosec/Synthroid/Nitrofurantoin/Midrin/HYZAAR/Methotrexate
Past Meds - Inderal/PTU/Prednisone/Voltaren/Feldene/Mobic/Cortisone and Steroid Shots/HCTZ


Ducky
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Date Joined Mar 2005
Total Posts : 3199
   Posted 9/10/2008 1:35 PM (GMT -7)   
Hey mom.. Here's the link on Lupus.. I see that BumbleBee already said something about it.. hopefully there will be more to follow.. Good luck!

Moderator of Arthritis Forum
Confirmed Diagnosis of - Psoriatic Arthritis/Spondylitis/Graves Disease/GERD/Scoliosis/Hiatal Hernia/Graves Disease of the Eyes/Chronic UTIs/Migraines/Hypertension
Current Meds -  Enbrel/Prilosec/Synthroid/Nitrofurantoin/Midrin/HYZAAR/Methotrexate
Past Meds - Inderal/PTU/Prednisone/Voltaren/Feldene/Mobic/Cortisone and Steroid Shots/HCTZ


momto3
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Date Joined Nov 2006
Total Posts : 1331
   Posted 9/10/2008 2:04 PM (GMT -7)   

Hi Ducky,

Thanks so much :) Getting a bit desperate here! I'm thinking about asking the rheumy if he gives out any of these others aside from the Plaquenil..I'm sure I'm not the only one who has asked for something that sounds a bit unusual. It's not the first time I've asked for something odd. Drinking a lot of caffeine and it just isn't doing the trick for whatever reason tongue


BumbleBee1
Regular Member


Date Joined Oct 2005
Total Posts : 130
   Posted 9/11/2008 3:57 AM (GMT -7)   
Hello :)

I have lupus affecting skin very badly, with arthralgia and extreme fatigue as the only major symptoms.
I have been taking Quinacrine for about ten years along with first Plaquenil, then Plaquenil's stronger cousin Aralen ( chloroquine). The combination has completely freed me from mild to moderate arthralgia, which is joint pain without swelling or redness, in knees, hips and lower back and hands. It cleared my skin and greatly reduced the fatigue.
I also take low dose Imuran.

Quinacrine can be an acceptable alternative to Plaquenil when there's a problem with eye toxicity or GI upsets.
Plaquenil replaced Quinacrine ( fka Atabrine) for anti malarial prophylaxis so Quinacrine was no longer manufactured into pills. It is used mainly for veterinary purposes these days. It can be obtained from a compounding pharmacist who will purify it for human consumption and make it up into pills or gel capsules.

I think we are not allowed to give links here but I hope it is OK to suggest googling for a paper written by Daniel Wallace who is one of the world's top lupus specialists. The paper is called "The Use of Quinacrine ( Atabrine) in Rheumatic Diseases" He says that hardly any trials of Quinacrine for RA have been done ( 1989)

Everything Dr Wallace says in that paper holds true today except they have found additional benefits.

I have never heard of anybody with RA using Quinacrine instead of Plaquenil, but why not? Plaquenil doesn't seem to be used all that much in RA compared with lupus. Perhaps one reason is that lupus rarely deforms joints but in RA agggressive treatment with more powerful drugs is essential to stop permanent damage.
Some of the drugs used in RA aren't suitable for use in lupus but I don't think that's true the other way round.


The other antimalarial used for rheumatic diseases is Aralen( chloroquine). It is chemically related to Plaquenil being rather stronger and with a greater risk of side effects so it isn't used much in the USA or Europe. It is not an alternative to Plaquenil for those reasons although it is sometimes used as a starter therapy in lupus for speedier effectiveness then changed to Plaquenil.

I don't know why doctors who prescribe Plaquenil either for lupus or RA aren't willing to prescribe Quinacrine instead or in addition.
It could mean not needing to use more toxic meds, or lower doses of steroids or drugs like Methotrexate with far greater short term and long term side effects. The bad side effects of the anti malarials are very rare and they have numerous highly beneficial side effects like reducing cholesterol, risk of diabetes, and slightly thinning blood so helping with atherosclerosis & heart attacks.

I don't know about RA but in lupus other causes for fatigue have to be investigated. Various anemias & B12 deficiency is commonly missed and can have a wide variety of very unpleasant symptoms some of them lasting. Thyroid problems are very common in lupus. Fatigue can also be caused by depression and lack of adapatation to living with disease and poor coping skills.



:)

Good luck and better health to all

Regards
BB

AlwaysRosie
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Date Joined Jan 2005
Total Posts : 8616
   Posted 9/11/2008 12:27 PM (GMT -7)   
idea  
 
This topic might behelpful to you too.
 
 
Blessings!


In His Grip

AlwaysRosie           "We can't control the waves, but we can learn how to surf!!"

Psalms 139

Co-Moderator - Lupus Forum

UCTD, Inflammatory Arthritis, Diverticulosis, (recent dx - Sjogrens, Crohn’s 4/08)

Clickable Links:  Lupus Resources    Lupous.Org   Lupus Criteria (4 of 11)   Lupus Chapter Locator


Ducky
Veteran Member


Date Joined Mar 2005
Total Posts : 3199
   Posted 9/11/2008 12:43 PM (GMT -7)   
Thanks Rosie! You're the best!
Moderator of Arthritis Forum
Confirmed Diagnosis of - Psoriatic Arthritis/Spondylitis/Graves Disease/GERD/Scoliosis/Hiatal Hernia/Graves Disease of the Eyes/Chronic UTIs/Migraines/Hypertension
Current Meds -  Enbrel/Prilosec/Synthroid/Nitrofurantoin/Midrin/HYZAAR/Methotrexate
Past Meds - Inderal/PTU/Prednisone/Voltaren/Feldene/Mobic/Cortisone and Steroid Shots/HCTZ


joinery
Regular Member


Date Joined Oct 2007
Total Posts : 323
   Posted 9/12/2008 9:27 AM (GMT -7)   
Hello momto3: I'm on the lupus forum and seen this post. Yes I've been on quinacrine for 7 months now I haven't had any problems with it so far. I also take plaquenil 400mg. Doc. did say you can turn yellow, but I'm doing good on the med. Hope this help's some.
Debbie
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