I started humira about 5 months ago and was also a bit worried about injecting it, but they come in a prepackaged ready to go pack, very easy to use, no visible needle to deal with. Its a pen with a spring loaded injection once you line up your pen just push the button and it injects for you. No depressing of needles or filling up from bottles etc... I'm sure enbrel will be the same. As for the effects I can't believe the difference. So much better than I was on just mtx plus sulphasolasine and arava. Now I'm just on mtx 10 mg and humira. I feel my quality of life is so much better its worth running the risks of side effects. Just have to be vigilent for infections, go and get antibiotics straight away if you're sick. Hope it works out for you.