Humira not working suddenly

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Alicat
Regular Member


Date Joined Aug 2008
Total Posts : 226
   Posted 2/21/2009 5:09 AM (GMT -7)   
I've been on Humira since last August.   It took a few months to kick in but then have been so much better.   A couple of weeks ago I skipped a shot and went to see my doctor because I thought I might have a sinus infection.   Was put on an antibiotic and when I went back to the doctor in a week he said I could resume my injections.   I took my shot that day and am due for another this coming Monday.   For the past week I have been miserable - pain and swelling everywhere - hands, knees, feet.
Could missing one injection have set me back that much or is something else going on??   So scared that I have to go back to all this pain again.
Anyone have any clue to what's happening?
 
thanks
 
Alicat
psoriatic arthritis, peripheal artery disease


psAinCanada
Regular Member


Date Joined Feb 2009
Total Posts : 34
   Posted 2/21/2009 9:32 AM (GMT -7)   

I hope you're feeling better soon.

My experience with PsA has been that it is totally unpredictable. I'll give you an example. Months ago, I had to go drug free because of liver problems. No MTX, no tylenol, no diclofenac. All I was allowed was 2 naproxen per day. I thought I'd be in huge trouble. In fact, I felt great for about three weeks. I started to ask myself why I had been taking all these drugs in the first place. Then after a few weeks of bliss, I had a massive psoriasis flare (and my first ever diagnosis of the pustular form of psoriasis) followed by terrible joint pain and swelling. Then I started Humira and I felt better in one week. Then I got sick again despite the Humira. Now I feel pretty good.

My rheumatologist and my dermatologist have both told me the same thing: that my symptoms flare and subside. And that the DMARDs can reduce the frequency and severity of the flares, but may or may not stop them. And that the improvement after one Humira shot was a coincidence.

So perhaps your dosing schedule caused your current woes, or perhaps it didn't. For me, it's unknowable, and this uncertainty is very hard. I actually wake up in the middle of the night sometimes and try to figure out how bad my joints are going to feel the next day. At least with the Humira I feel like I'm doing everything I can to make it better.

Good luck.


Healing well with psoriasis, PsA, and hypogonadism, and happy to share my experiences.
 


golitho
Veteran Member


Date Joined Sep 2008
Total Posts : 1670
   Posted 2/22/2009 7:13 PM (GMT -7)   
Hi Alicat, I've been going through the same thing. Stable on humira and mtx then caught pneumonia had to come off everything for weeks, My joints flared terribly took nearly 10 weeks plus prednisone to get back under control. Then caught bronchitis recently missed 1 dose of humira and flared again!!! I see my rheumy today to hear her approach this time. I'm getting really depressed at my inability to stabalise. This low immunity is playing havoc with my body, I'd love to get fit but always seem to be flaring and incapable of much exercise. Then once I'm on top of the flare seem to catch something again before I get a chance to build my health up!!! So I have no advice but can share a grumble and yes missing that one shot always sets me back. My rheumy told me we should get to a stage where we can miss a shot and not notice it, but unfortunately it hasn't happened for me yet. Are you just on humira?

Alicat
Regular Member


Date Joined Aug 2008
Total Posts : 226
   Posted 2/23/2009 3:32 AM (GMT -7)   

Hi golitho,

I still take Alleve twice a day.  That's the only thing I take for the Arthritis other than the Humira.    Just had another restless night's sleep.  It's so depressing to have the pain back in my knees and hands again.    I'm due for an injection today and am praying it kicks in.

I still am not feeling great otherwise either.   Still have a cough and some times discomfort in my chest.   Too bad they can't come up with a drug that would relieve our suffering without compromising our immune systems.

thanks for responding.   Hope you have a great - pain free week.

 

Alicat


psoriatic arthritis, peripheal artery disease


golitho
Veteran Member


Date Joined Sep 2008
Total Posts : 1670
   Posted 2/23/2009 5:15 PM (GMT -7)   
Hi Alicat, I saw my rheumy and she gave me this complicated explanation about humira and its half life in our bodies and once we miss a dose the half life starts depleating and then we have to build up to that half life again. It makes more sense when you see a graph. She has tried me on a new NSAF called  Mobic and bumped up my dose of mtx as I'm definately not stabalised at the moment so hopefully in a few more weeks I'll be ok again... as to your chest pain and cough. My chest guy told me to have a sputom(?) sample every time I get a cough to double check the right antibiotic has been given. Plus I got a severe bout of costichondral arthritis with the pneumonia which was basically bad rib pain. My rheumy gave me 4 shots of cortisone into the hotspots plus big doses of prednisone before it settled. It was horrendous, hurt to breathe, sleep, sit everything, took weeks to recover. I really hope thats not what you're suffering from. I've had two doses of humira since my missed dose and it still hasn't kicked in but she said its extremely rare for it to stop working. She is still confident it will suddenly kick in again. I hope yours does soon. Regards J

Alicat
Regular Member


Date Joined Aug 2008
Total Posts : 226
   Posted 2/23/2009 5:45 PM (GMT -7)   
Hi golitho,
 
took my humira injection this morning and am  hoping it will kick in soon.  Not quite as much pain today as I had yesterday.  Weather is affecting me too, I know.
Hope you'll feel better soon also.  Thanks for the info.
 
Alicat
psoriatic arthritis, peripheal artery disease


golitho
Veteran Member


Date Joined Sep 2008
Total Posts : 1670
   Posted 2/26/2009 5:27 PM (GMT -7)   

Hi Alicat

So pleased to hear your pain is subsiding. I'm still struggling along trying to be positive, bit worried about going back to teaching next week, my hips really hurt! I'll have to rethink my teaching methods. Hopefully the next dose of humira will do the trick for me and I'll be back to my normal mad self, flying around with limitless energy. I can only dream. I'm trying to remember the last time I missed a dose how long it took to kick back in, at least I now know it will eventually. Thanks for your responses, I'm not normally this low and it does help to share.


Blu021
Regular Member


Date Joined May 2004
Total Posts : 58
   Posted 3/1/2009 8:40 PM (GMT -7)   
I've been on humira for about four years now....sometimes I flare right after an injection...but I think it keeps it at a tolerable level compared to what I use to deal with. I have done a dose a day or two late...nothing serious happened. But I can imagine that skipping a dose for a week or two could cuase a flare. Good luck....it's good stuff.
21 year old female
Diagnosed with UC at age 16
Diagnosed with RA at age 18
Now dealing with HPV and possible cervical dysplasia
Medications: 6MP 75 mg, Asacol 2 tablets a day, Humira shots every two weeks

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