Given the choice, I'd recommend the cortisone injections. I've been on prednisone for extended periods in the past, and it never helped my joint pain. I recently had a cortisone injection into my very badly damaged right knee, and it is almost pain-free for the first time in five years. Also, the injections have less systemic effect and are less likely to cause some of the serious side effects of Prednisone.
You need to give the anti-depressants at least a couple of weeks. They could kick in sooner, but often it takes two weeks.
Moderate to severe left-sided UC (21 cm) diagnosed 2001.
Avascular necrosis in both shoulders is my "forever" gift from Entocort.
Colazal, Remicade, Nature's Way Primadophilus Reuteri. In remission since April, 2006.
"My life is an ongoing medical adventure"
Co-Moderator UC Forum
Please remember to consult your health care provider when making health-related decisions.