I have also had RA for a few years now and a on Monday morning of this week, I woke up with no joint pain..none! I thought I was in remission or it was gone. So I hopped on the tread mill, and the next morning it was all back full force and has been ever since. I'm also on MTX and other than that one day, I have never went a day with pain/stiffness or fatigue. My rheumy tells me it is virtually impossible and so yes in my case I've taken just about everything even the biologics and still flared. It can be dissapointing I know, but like SJ mentioned it is so different for each individual. There is a lady on the moanin board who is on the Enbrel and able to do kickboxing on a regular basis, I can go to the gym but find the next day I'm sitting it out. It just depends on the treatment and the person.