Hey there, i added Arava as a supplement to Plaquenil. Arava is in the same drug family as Methotrexate. It helped quite a bit, however, in my case I had a rare reaction - it affected my blood pressure. I have a naturally low blood pressure and it started creeping up after a year on the med....I kept asking the docs about it and they told me to 'keep an eye on it' every time...well, it continued to rise over 8 months time and still nobody thought it could be the drug, they kept saying it was my weight. Long story short, my BP rose enough to land me in the ER one night. I did research, stopped the Arava on my own and saw a small improvement within 4 days. All the doctors were shocked, I think some still don't believe me. It also caused severe GI (reflux) issues.
Anyway, just be aware of your body while on it, and if things start happening for the worse, don't disount a medication may be causing it.