has anyone tried Simponi?

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koi collector
Regular Member


Date Joined Oct 2008
Total Posts : 35
   Posted 1/11/2010 7:39 AM (GMT -7)   
I've been on Enbrel for 12 months now my doc wants to try me on Simponi because of injection site reactions from Enbrel.
has anyone tried Simponi yet?
Thank you for the input.

golitho
Veteran Member


Date Joined Sep 2008
Total Posts : 1670
   Posted 1/11/2010 2:01 PM (GMT -7)   
Sorry Koi, I haven't heard of Simponi. But I'm always interested as my beloved humira has stopped doing its thing. Is simponi the same strength or a stronger biological?

Hope someone here has more info for you, golitho
 
Hey Koi, just realised Penelope Yukon is on it and Jo was mentioning it in relation to the Crohns site. Check out Penelopes posting.

Post Edited (golitho) : 1/11/2010 2:05:37 PM (GMT-7)


golitho
Veteran Member


Date Joined Sep 2008
Total Posts : 1670
   Posted 1/12/2010 1:30 PM (GMT -7)   
Hi Koi, I looked it up. It sounds really good. Human based protein and only once a month. I'd go for it. I found I had less reaction to the actual injections rather than the pens with humira. I always got a rash with the pens.

Hope this helps, golitho

teddybearweiser
Veteran Member


Date Joined Oct 2004
Total Posts : 3042
   Posted 1/13/2010 8:26 AM (GMT -7)   
Hi Koi, I only heard about it from a tv add for it. Only once a month injection.
Hi, I am teddybearweiser, I am a male.
I was diagnosed with crohns disease when i was admitted to the hospital

in 1992, in Jan of 1993 I was back in the hospital for surgery for my crohns. I had part of my right colon resectioned with ilecolonstomy.

My GI doctor has me on and Humira. B-12 injection once a month.
Also diagnosed with Rheumatoid Arthritis.


Ides
Forum Moderator


Date Joined Nov 2003
Total Posts : 7077
   Posted 1/13/2010 4:19 PM (GMT -7)   
I have been taking Simponi since June 2009. I have had a total of eight injections. Simponi is injected once a month. I have had NO injection site reactions. I have no burning at the site following the injection. I was on Remicade for 2.5 years before it stopped working. I took Humira for 2.5 months until I developed a massive reaction necessitating stopping it. All of these were use to treat my Ankylosing Spondylitis.

Remicade gave me a great remission. Humira didn't seem to do anything. I was off all TNFs for 15 months before I started the Simponi. I have had a great response and lots of relief.
Moderator Crohn's Disease  & Osteoarthritis Forums
CD, Ankylosing Spondylitis, lupus, small fiber peripheral neuropathy, avascular necrosis, peripheral artery disease, degenerative disc disease, asthma, severe allergy and a host of other medical problems.
 


koi collector
Regular Member


Date Joined Oct 2008
Total Posts : 35
   Posted 1/25/2010 2:55 PM (GMT -7)   

Ides,

How long did it take for Simponi to kick in?

i've been off enbrel for more than 2 weeks now and on Simponi for 10 days. so far i feel my neck and ribs more than i'd like too.

I guess the Simponi hasn't kicked in yet. at least my knees don't hurt to much.

thank you


Ides
Forum Moderator


Date Joined Nov 2003
Total Posts : 7077
   Posted 1/26/2010 1:31 PM (GMT -7)   
I felt a moderate amount of relief within 10 days of my 1st Simponi injection. Five days after my second injection I felt 85% better than I did pre-Simponi. Hope it kicks in soon for you. Also, are you taking methotrexate in conjunction with the Simponi? I read that MTX with Simponi is the recommended course for those with RA. In fact I had a fight with my insurance company over the matter. They said I HAD to be on MTX if I was going to use Simponi. Because I have AS, not RA, that stipulation was waived.
Moderator Crohn's Disease  & Osteoarthritis Forums
CD, Ankylosing Spondylitis, lupus, small fiber peripheral neuropathy, avascular necrosis, peripheral artery disease, degenerative disc disease, asthma, severe allergy and a host of other medical problems.
 


koi collector
Regular Member


Date Joined Oct 2008
Total Posts : 35
   Posted 1/26/2010 3:08 PM (GMT -7)   
Ides,
well I'll find out how it works without MTX for now because we're trying for a second child and MTX is not good for that.
thank you for the followup. its too bad Enbrel started having side effects for me but i can take it in stride for now because it's no where near as bad so far before Enbrel. i can still walk and play with my son this time.
on to better days for all of us!!! :)

Ides
Forum Moderator


Date Joined Nov 2003
Total Posts : 7077
   Posted 1/27/2010 5:47 PM (GMT -7)   
Love your screen name - koi collector. I love koi and used to have some in a pond in my yard until the raccoons ate them. hopefully the Simponi will soon bring you increasing relief.
Moderator Crohn's Disease  & Osteoarthritis Forums
CD, Ankylosing Spondylitis, lupus, small fiber peripheral neuropathy, avascular necrosis, peripheral artery disease, degenerative disc disease, asthma, severe allergy and a host of other medical problems.
 


Raven67
Regular Member


Date Joined Sep 2007
Total Posts : 155
   Posted 1/30/2010 12:28 AM (GMT -7)   
Ides, Glad to hear you've had relief with Simponi. I am starting it next month and quite anxious. I've tried quite a few combinations and so far nothing has worked.
I hope this goes better.

Raven
When you get to the end of your rope, tie a knot and hang on!!!!
 
Current Diagnosis- DCIS, Rheumatoid Arthritis, Insulin Dependent Diabetes, Osteoarthritis right knee, Osteoporosis. Stress!!!!!!  New diagnosis of Fibromyalgia 04/08
Current Meds-Methotrexate 24mg s/c weekly, Plaquenil 200 mg BID, Celebrex, Folic Acid daily, Cesamet1 mg @ bedtime, Oxycontin 20 mg 3 x day, Lorazepam 2 mg dly Actonel weekly, Insulin-Humalog 35 units TID and Lantus 40 units BID, Calcium, Vitamin D  Arava 20mg daily


RA-SS-help
New Member


Date Joined Jun 2011
Total Posts : 3
   Posted 6/2/2011 7:35 AM (GMT -7)   
My wife started taking Simponi and Methotrexate and Folic Acid about 2 months ago and we haven't seen much help yet. In fact she has been getting worse this week. She also had been taking Enbrel before the Simponi and had the same reactions at the injection site. Just saw the rheumatologist and gave her more blood for tests. Hopefully the Simponi will kick in. Ugh!

Alicat
Regular Member


Date Joined Aug 2008
Total Posts : 226
   Posted 6/5/2011 9:35 AM (GMT -7)   
I have to start on Remicade as my Humira isn't working anymore. Recently have psoriasis on my skin. Anyone out there on Remicade and has it helped or hindered?

alicat
psoriatic arthritis, peripheal artery disease

De La Rosa
Regular Member


Date Joined Mar 2009
Total Posts : 235
   Posted 6/9/2011 7:59 AM (GMT -7)   
RA-SS-help, did your wife feel any relief from the Enbrel, before the injection site reactions? I've been on so many of these injectable drugs, and I have to say none have made me feel any better. I started on Remicade infusions, then went to Enbrel, then to Humira, and now I'm on Cimzia. I really have never seen nor felt any improvement. I have also taken methotrexate, same...didn't feel any better.

The only reason I'm asking is because these drugs seem to be touted by everyone as such "wonder drugs", and I felt like I was the only one who wasn't getting any relief after taking them. Its really disheartening to start on one of the "miracle drugs" and wait and wait and not seem to get any better.

Post Edited (De La Rosa) : 6/9/2011 9:02:42 AM (GMT-6)

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