Enbrel allergic reactions

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Austin Misha
New Member

Date Joined Feb 2010
Total Posts : 7
   Posted 2/26/2010 2:35 PM (GMT -6)   
Has anyone had allergic reactions to Enbrel? After the 2nd injection I had noticed my face getting red and having some irritation/rash on my chest, face and arm. Within 30 minutes of the the third injection, my face turned beet red and felt feverish and swollen. The next day my forehead was peeling and my face was still flush and irriated, but not as much. . My Dr. has told me to go off the Enbrel and start another medication. I have an appointment next week to discuss options. However, I was wondering if any has had allergic reactions to Enbrel and if so how did they manage it--did you have success with another biologic drug?

Veteran Member

Date Joined Mar 2005
Total Posts : 1884
   Posted 3/5/2010 11:46 AM (GMT -6)   
Wow, that is scary. I haven't tried Eenbrel  yet, though they want me to. Are you doing better?
The biologicals are all different, how you react to one, is not necessarily how you will react to another. At least that's what everyone insists. :-)
It seems someone once did have a reaction, but i cannot remember who it was or if it was someone here on HW. I'm sorry I'm not much help.
Let us know what the doctor says - and BTW, welcome to HW!  

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Date Joined Nov 2003
Total Posts : 7056
   Posted 3/5/2010 8:05 PM (GMT -6)   
That is a reaction unlike any others I have read about. I have not tried Enbrel but have used Remicade, Humira, and am now take Simponi - all biologic meds. I had a major reaction to Humira. I had to go on prednisone to control the symptoms of the reaction. I did have a fever, but no swelling of my face. I had massive joint swelling and pain, extreme fatigue, and a rash. I lost feeling in my feet and legs that caused me to fall upon standing and break my leg. It was a nightmare.
Moderator Crohn's Disease  & Osteoarthritis Forums
CD, Ankylosing Spondylitis, lupus, small fiber peripheral neuropathy, avascular necrosis, peripheral artery disease, degenerative disc disease, asthma, severe allergy and a host of other medical problems.

Veteran Member

Date Joined Mar 2005
Total Posts : 1884
   Posted 3/5/2010 8:45 PM (GMT -6)   
Holy cow! are you okay now?

Regular Member

Date Joined Aug 2008
Total Posts : 226
   Posted 3/15/2010 6:01 PM (GMT -6)   


I was put on Enbrel first and after a few injections the injection site swelled all up, it was raised, hot, red and about the size of a baseball. The rheumatologist told me to stop it right away and thought I might be allergic to some of the preservatives they use in it.   She switched me to the Humira and I haven't had any problems with that.   Been on it for almost two years now.   Once in awhile the injection site is a little itchy for a day, but that's about it.    Humira is the same type of drug as Enbrel but you might want to ask your doctor if he/she thinks it might have been something in the preservatives and if Humira might be worth a try.

Good luck


psoriatic arthritis, peripheal artery disease

New Member

Date Joined Mar 2010
Total Posts : 6
   Posted 3/16/2010 10:23 PM (GMT -6)   
My only issue was a UTI about week three. It seems like the injection site is "feverish" for about 24 hours, which has always kind of freaked me out. It sounds like each reaction is worse than the previous for you. I'm anxious to hear the options they discuss...
Living with: Ankylosing Spondylitis
Getting help from: Enbrel, Indomethacin, Toprol, Teveten
Hoping for: As many sunny days as cloud ones.

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