Does Plaquenil cause fatigue or fever?

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Regular Member

Date Joined Jan 2010
Total Posts : 64
   Posted 5/5/2010 11:41 AM (GMT -6)   
Hi everyone, I have fibro and RS and Sjoegren's. I have been on Plaquenil for a little over 2 months now. I can say that I am not having pain like I used to, and I am so grateful for that! The problem now is the undending fatigue! I don't know if this is just the RA in full swing, or if it is a side effect of the Plaquenil. I have been running a low-grade fever (around 99.8) for about a week and a half now. It comes & goes and I can tell when it is up because I feel hot. My normal body temperature is low, around 97.5, so I don't know if 99.8 would be considered a fever.
  I have found that I really have to take care every day to decide what I am going to expend my energy on. I can do 10-15 mintues of cleaning, then I have to sit down & rest. If I go out somewhere to run an errand, I know that I will need a nap later. I go to bed earlier & earlier, I used to watch shows that came on at 9 pm, but I always conk out about about 9:40. The fatigue is undending and I just don't have energy to do anything. Is this just a part of RA or could it be the Plaquenil? I know it takes a while to build up in your system. How do you deal with the fatigue? It's really frustrating!
Diagnoses: Depression/Anxiety, PTSD, Hypothyroidsim, High Blood Pressure, Fibromyalgia, Raynaud's, Rheumatoid Arthritis, Osteoarthritis, Sjogren's
Meds: Celexa (once a day), Buspar (2x a day), Levoxyl (once a day), Metoprolol (once a day), Lyrica (3x a day), Plaquenil (2 times day), Clonazepam to help me sleep for the moment until I find something else.
Allergic to: Sulfa, Ceftin, Augmentin, and Synthroid (probably the filler).

Regular Member

Date Joined Mar 2010
Total Posts : 72
   Posted 5/5/2010 12:20 PM (GMT -6)   
Hi Moggy914 - I have RA and my teenage daughter has fibromyalgia. I think fatigue is a big part of everything you have. AT times I have had that debilitating fatigue. My daughter still deals with it - she is housebound. My rheumatologist told me that once the inflammation is under control my fatigue will improve. He's been right. I believe my inflammation is up now and I have been in more pain and experiencing more fatigue. I take Plaquenil along with (prednisone, methotrexate, and Humira). None of these meds make me fatigued. I believe its the illness that causes my fatigue and my daughters fatigue. I suspect that holds true for you too. Maybe someone else will tell you differently, but I haven't known anyone else that found Plaquenil to make them tired. Pace and rest when you can and if you can exercise a little try to do that. My daughter couldn't exercise at all until recently. Now she can just a little. I was able to always exercise even when I was so swollen. It just made me feel good that I did something for me. When I was at my worst I didn't exercise as much, but I kept walking. I did some yoga but some positions I couldn't do. I just prided myself on trying and doing what I could. Oh, a couple of your other meds might make you tired, but I don't think Plaquenil will. Best of luck to you.


Veteran Member

Date Joined Dec 2007
Total Posts : 2113
   Posted 5/12/2010 8:37 PM (GMT -6)   
Plaquenil is the only thing that ever got rid of the fatigue and random fevers for me.
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