Humira question

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TakeCare
New Member


Date Joined Aug 2010
Total Posts : 5
   Posted 8/31/2010 12:13 PM (GMT -7)   
Hello Board,
 
I am new to posting on this site.  I am very grateful for to be able to be connected with other's who share similar experiences.  I have had RA for 6 years.  I am wondering if anyone has experienced stomach pain or abdominal problems from Humira.  My doctors are checking out everything to see what is causing my abdominal pain and not coming up with anything definitive yet.  The only thing that has changed recently for me is starting Humira.  I also take prednisone, plaquenil, methotrexate and folic acid. 

JayBespoke
Regular Member


Date Joined Jul 2010
Total Posts : 297
   Posted 8/31/2010 12:20 PM (GMT -7)   
Sorry I can't help with Humira, except to say that an upset stomach sounds extremely atypical to me.

What dosage/indication of MTX are you taking? MTX can and does cause abdominal pain, and it can occur at any time during MTX treatment (ie something doesn't need to change).

Plaquenil can cause stomach upset, and taking with food/milk will help alleviate this.

Are you taking any NSAIDS like Ibruprofen (Advil) or Diclofenac (Diclofex), or other analgesics like Tramadol (Ultram), or Paracetamol (Acetaminophen/APAP)? All of these can cause stomach upsets, especially the NSAIDS.

take care

James
21, Male, England.
Dx: Psoriatic Arthritis, Fibromyalgia, Dyspraxia
Rx: 50mg Etanercept (Enbrel) Sub-Cut Injection, 7.5mg MTX, 25mg Amitriptyline

Oh, and plenty of Tramadol, Dihydrocodeine, Domperidone, Hydroxyzine, and Scotch

Contact: facebook.com/ jabutler // burnley219 (at) googlemail.com (Anti-spam)
Feel free to contact me for any reason, unless you're in sales!

TakeCare
New Member


Date Joined Aug 2010
Total Posts : 5
   Posted 8/31/2010 12:42 PM (GMT -7)   
Thank you for your response,

The Humira dose is 40mg every 2 weeks. I had been taking 8 tabs 2.5mg of Methotrextae but just recently lowered to 6 tabs weekly. Have'nt had to take NSAIDS for about 6 months now. It is so frustrsting.

JayBespoke
Regular Member


Date Joined Jul 2010
Total Posts : 297
   Posted 8/31/2010 12:48 PM (GMT -7)   
Has lowering the MTX dosage helped at all?

Have you had comprehensive blood work done?
21, Male, England.
Dx: Psoriatic Arthritis, Fibromyalgia, Dyspraxia
Rx: 50mg Etanercept (Enbrel) Sub-Cut Injection, 7.5mg MTX, 25mg Amitriptyline

Oh, and plenty of Tramadol, Dihydrocodeine, Domperidone, Hydroxyzine, and Scotch

Contact: facebook.com/ jabutler // burnley219 (at) googlemail.com (Anti-spam)
Feel free to contact me for any reason, unless you're in sales!

TakeCare
New Member


Date Joined Aug 2010
Total Posts : 5
   Posted 8/31/2010 1:11 PM (GMT -7)   
So much blood work. My PCP took blood work, my Rheumy constantly monitors blood, and the GI has taken blood work and is about to take more because after the last test, which was an MRCP of the abdomin, they found a dialated intra hepatic duct and they were trying to find out if there is a stone or something blocking it. Apparently there is nothing blocking it but they are going to take more blood work and possibly do an ERCP now.

JayBespoke
Regular Member


Date Joined Jul 2010
Total Posts : 297
   Posted 8/31/2010 2:30 PM (GMT -7)   
Well, I'm stumped. Though I'd be willing to bet on Hydroxychloroquine or Methotrexate as being the culprit.

Edit: Sorry, I slipped into English. Hydroxyblahblahblsh = Plaquenil. And I wouldn't really bet on your health, unless I had really good odds.

I hope it's something trivial, take care

James

sjkly
Veteran Member


Date Joined Dec 2007
Total Posts : 2113
   Posted 8/31/2010 3:53 PM (GMT -7)   
Hydroxychloroquine and Mtx would both cause GI problems as would prednisone. I doubt Humira would.

Nana Monster
Veteran Member


Date Joined Jul 2009
Total Posts : 952
   Posted 8/31/2010 5:19 PM (GMT -7)   
I haven't taken it but I got a "free sample" thing for it in the mail and just love the fact it can actually give
you TB. Scares the crap out of me. shocked

Bstrong
Regular Member


Date Joined Jul 2010
Total Posts : 107
   Posted 8/31/2010 6:28 PM (GMT -7)   
It can give you TB and there was something about cancer too right? as I remember... My Humira is in the fridge and in two weeks I can take first injection. And of course I will go for it! Hope it will work with no side effects and give me normal life. There is so many medication out there with so many side effects but well... it is always risky ... as RA without treatment.
TakeCare - I hope you'll find what causes the abnominal pain, keep us posted!

Post Edited (Bstrong) : 8/31/2010 7:31:12 PM (GMT-6)


TakeCare
New Member


Date Joined Aug 2010
Total Posts : 5
   Posted 9/1/2010 7:23 AM (GMT -7)   
Thanks everybody. It really does help just to have poeple who will listen and empathize with you. :>

JayBespoke
Regular Member


Date Joined Jul 2010
Total Posts : 297
   Posted 9/1/2010 7:59 AM (GMT -7)   
Any time! it can be so frustrating when you have nobody to speak to who has any idea what it's like! Until last week I had long standing undiagnosed back pain, turns out to be Fibromyalgia - but I know just knowing what is causing the discomfort actually provides some relief - just being able to label it seemed to help me.

Bstrong, I had to have a TB scratch test (really stings!) before starting Etanercept, is that not the norm? (Chest X-ray too)

take care
21, Male, England.
Dx: Psoriatic Arthritis, Fibromyalgia, Dyspraxia
Rx: 50mg Etanercept (Enbrel) Sub-Cut Injection, 7.5mg MTX, 25mg Amitriptyline

Oh, and plenty of Tramadol, Dihydrocodeine, Domperidone, Hydroxyzine, and Scotch

Contact: facebook.com/ jabutler // burnley219 (at) googlemail.com (Anti-spam)
Feel free to contact me for any reason, unless you're in sales!

wearyRAsufferer
Veteran Member


Date Joined Mar 2010
Total Posts : 2322
   Posted 9/1/2010 6:56 PM (GMT -7)   
Before Humira I had to have the under the skin injection TB test twice! Done 2 weeks apart or was it 21 days?

Bstrong
Regular Member


Date Joined Jul 2010
Total Posts : 107
   Posted 9/1/2010 8:12 PM (GMT -7)   
Yes I had the under skin TB test injection - once I am not sure what TB scratch test is???... And as I am originaly from Poland where we got vaccine for the TB it showed that I am positive as it stays in the body forever... Chest x-ray also was done - everything normal, but as my rheumy said I need to take Isoniazid before starting Humira to just exclude any posibility of TB... After 1 month of Isoniazid you can start Humira, but you need to take Isoniazid for 6 months.... bleee, but OK whatever... He had some bad experience with one of the patient and he is very careful so I am going for it. As far as I know taking Humira can higher your risk to get TB or if you already have (hidden one) it can turn in very serious condition. Correct me if I am wrong, I just read the info from Humira once and don't remember everything.
Polyarthritis - diagnosed July 2010, suffering from May 2009

Prednisone - 10mg/day, Plaquenil, Vitamin D, Fish Oil, Isoniazid - getting me ready for Humira, also Prednisone shots ocasionally.

Pain - off and on

JayBespoke
Regular Member


Date Joined Jul 2010
Total Posts : 297
   Posted 9/2/2010 12:51 AM (GMT -7)   
BStrong, the scratch test is just when they inject it under the skin like you say. They inject the solution and look for an abreaction after 48 hours to allow it to settle. I have also had the TB vaccine, I thought every one did?

All biologics pose a very serious threat to those who are carrying TB, or are exposed to it, so they are very prudent - though I'm surprised it's normal protocol to take Isoniazid for 7 months!!
21, Male, England.
Dx: Psoriatic Arthritis, Fibromyalgia, Dyspraxia
Rx: 50mg Etanercept (Enbrel) Sub-Cut Injection, 7.5mg MTX, 25mg Amitriptyline

Oh, and plenty of Tramadol, Dihydrocodeine, Domperidone, Hydroxyzine, and Scotch

Contact: facebook.com/ jabutler // burnley219 (at) googlemail.com (Anti-spam)
Feel free to contact me for any reason, unless you're in sales!

Bstrong
Regular Member


Date Joined Jul 2010
Total Posts : 107
   Posted 9/2/2010 4:39 AM (GMT -7)   
What I've heard we got vaccinated in Europe, but here in America they don't also people from Asian countries will get the vaccine. I am not sure though - just 6 years in USA :) maybe some native American will confirm 100%

So I am assuming JayBespoke that you were positive too right? I hate taking Isoniazid for that long, knowing actually that the vaccination caused the test to be positive... I taked to my rheumy about it but he wants m to take it anyway. Maybe I should do some more research and save my liver this way, but he said it is too much risk involved and I don't want any risk...
Polyarthritis - diagnosed July 2010, suffering from May 2009

Prednisone - 10mg/day, Plaquenil, Vitamin D, Fish Oil, Isoniazid - getting me ready for Humira, also Prednisone shots ocasionally.

Pain - off and on

wearyRAsufferer
Veteran Member


Date Joined Mar 2010
Total Posts : 2322
   Posted 9/2/2010 5:08 AM (GMT -7)   
I am a life long American and I have never received a vaccination for TB.

JayBespoke
Regular Member


Date Joined Jul 2010
Total Posts : 297
   Posted 9/2/2010 7:14 AM (GMT -7)   
BStrong - I was negative. The criteria was that the mark left after 48 hours had to be smaller than 2x2cm, or something like that.

I just assumed that if all of Europe do it, and various Asian/African countries I've visited (I've seen the vaccination scar on people abroad, to anyone who hasn't had the vaccine, it usually scars you for life, literally!) do, then everyone must! Naivety on my part there :)
21, Male, England.
Dx: Psoriatic Arthritis, Fibromyalgia, Dyspraxia
Rx: 50mg Etanercept (Enbrel) Sub-Cut Injection, 7.5mg MTX, 25mg Amitriptyline

Oh, and plenty of Tramadol, Dihydrocodeine, Domperidone, Hydroxyzine, and Scotch

Contact: facebook.com/ jabutler // burnley219 (at) googlemail.com (Anti-spam)
Feel free to contact me for any reason, unless you're in sales!

Bstrong
Regular Member


Date Joined Jul 2010
Total Posts : 107
   Posted 9/2/2010 5:10 PM (GMT -7)   
Thanks wearyRAsufferer!, yeah that's what I have heard no Americans receive TB vaccine.

It was strange because my skin after TB test looked totaly diffrent 3 years ago and totally different now after the test. Maybe because my immune system now the reacton was very strong - I had the mark for sure over 2cm in diameter and it was red little blisters filled with some fluid. I couldn't believe as 3 years earlier I had same test and the mark was red, little bit swolen but wasn't more than 1cm or something. Well, my chest x-ray was fine... who knows...
Polyarthritis - diagnosed July 2010, suffering from May 2009

Prednisone - 10mg/day, Plaquenil, Vitamin D, Fish Oil, Isoniazid - getting me ready for Humira, also Prednisone shots ocasionally.

Pain - off and on

Nana Monster
Veteran Member


Date Joined Jul 2009
Total Posts : 952
   Posted 9/9/2010 6:05 PM (GMT -7)   
I'm from America too and have never had the vaccine. I'm tested every year at work as I'm in a nursing home,
even though I'm kitchen help. Humira can be a very nasty drug with side effects including blood disease, kidney
and liver disease or failure, heart disease or failure, various types of cancers, TB and a host of others. I think I might
have thrown the brochure away but it was truly frightening. Personally, I'm sticking to plants as much as possible.
I only take Darvacet and Skelaxin when absolutely necessary.

Nana Monster
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