Ankylosing Spondylitis Mediciation not working

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swon888
Regular Member


Date Joined Jun 2010
Total Posts : 91
   Posted 9/11/2010 7:39 PM (GMT -7)   
In my other post, I had explain that my ankylosing spondylitis has suddenly flare up and the medicine I had been using has no effect on it any longer. I was on Remicade every 6 weeks, it was working fine up until this year, now I still get Remicade, but it only last me for 10 days, than all my pains starting to come back. Anyway, last week I went to visit my doctor, he gave me some Neurontin 100mg 3 times a day and Tylenol with codeine (vicodin give me problems). I was wondering has anyone ever taken this combination of meds and what kind of results do you have. as for me, the medicine has no effect on me, did not help a bit in terms of the pain, but it gives me a little more problem. day 1 seems to be fine, just a little drowsy as expected, day 2, same, but day 3, I was getting a bit discomfort from my chest and a little short of breath, it happen twice doing the 2 times I took the pills. I guess I will stop the pills and call my doctor on Monday. The worst part for me is I also have GERD, a lot of acid and gas is pushing up and make me very uncomfortable at times. some times I can not tell the discomfort is coming from the meds or my stomach. Any advice or suggestion would help. thank you.

grainofsalt
Regular Member


Date Joined Aug 2010
Total Posts : 215
   Posted 9/12/2010 9:38 AM (GMT -7)   
Hi Swon,

While I do not know for sure whether I have the SA version of RA, I had lidocaine tests done that indicated I had RA not to mention I had a Radio Freq Neurotomy done on one side of my back (the other side to be done in 3 weeks) and it is helping a lot to relieve the pain and inflamed feeling that starts where the lower back meets the buttocks and goes down the upper part of the leg, and sitting feels like "Hell" literally (walking can be heaven); so of the types of RA, that seems to be the closest to my symptoms.

Everyone responds differently, but generally with me Ive found steriodal anti inflamatories bring the most relief (corti shots, presndone - though the latter seems to wear off too quick), followed by nueropathic opioids (by this I mean Nycynta/Tapentadol first choice and and Ultram/Tramadol second choice as its noticably weaker), followed by NSAIDs, followed by weak opioids (codeine, hydrocodone), followed by Tylenol. Personally, I don't feel codeine is a good pain reliever for something as severe as RA disorders, unless the symtoms are only mild to moderate.

For Moderate to severe pain, it will barely take the edge off of the pain. As for Nuerotin, I have never been on it so I can't honestly say. The medication I take Nucynta would be a more suitiable opioid than codeine for pain related to SA/RA because its has two mechanisms of action, the traditional morphian receptor activation, and norephedrine reuptake inhibitor action. NE action very useful to some individuals with inflamed nerves (as it is thought to have a blocking action on nerve pain) and therefore by reducing the preceived pain helps the opioid side of nucynta work better. Thats what's worked for me, but EVERYONE is different.
MRI revealed a bulging disc w/gel lost at L5 and showed the bulge touching nerves, causing sciatica. Diagnosed w/ Arthritis which is responsible for joint inflamation pain. Treatment: Nucynta 50-150 mgs every 6 hours (schedule II narcotic, Mu Opoid agonist and NE reuptake inhibitor), Celebrex 100 mgs, Klonopin .5, Epidurals, Radio Freq nuerotomy (sept 8th, 2010)

swon888
Regular Member


Date Joined Jun 2010
Total Posts : 91
   Posted 9/14/2010 9:16 PM (GMT -7)   
Thank you for your reply. I was told by my doctors in most cases, the treatments are the same between most of the arthritis.

as for meds, I tried presndone last month, it did not do much help. I was also on Codeine. Vicodin give me a bit of heart beating, sweating and nausea feeling. I have to agree, vicodin does work better than codeine. for some reason, my body for the last year had been very sensitive to medicines. in the pass, I was taken 2 vicodin per day, sometimes less with out any problem, but now, even a quarter of it makes me worry. the NSAIDs works for me as well, but again my body reacts to it as well. Celebrex 200mg almost sent me to the hospital. my body reacts ok to Mobic, but the problem with that is it makes my stomach and colons bleed. Either way I can not win. I can only try what my doctor give me now and in the mean time, I just have to deal with my pain until the doctor give me something better. I'm just running out of options.
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