Elaine, I'm sorry you're having difficulties right now, and I hope you're feeling better soon. I have never taken Remicade, but was on enbrel for many years (same class as drug as remicade, TNF-inhibitor). Enbrel stopped working for me as well. I asked about being switched to remicade but doctor said it was the same class as enbrel so it didn't make any sense to try another tnf-inhibitor. He started me on orencia, which is a biologic but it is not a tnf-inhibitor. I'm really not sure how the drug works. I've only had two infusions so far, so not feeling the major effects yet, but I'm also on mtx and anti-inflammatories. Orencia, evidently like the other DMARDs, takes a while to build up in your system.
But know that we have drug therapy options that were not possible even 10 years ago. There are many more options available to us today, so it's just a matter of finding the right drug combo that works for you.