I was on SAM-e 400mg once a day (Amino Acid - over the counter, very safe, you can buy it in the supplement/herbal isle at any grocery store or Drug store) It is natural, that our bodies produce, but declines as we age. I was on it for three years for joint support and depression. It worked wonderfully for both depression and my joints. My chronic lower back pain went away, as did the intermittent pain in my wrists and fingers. If you would like to know more about it, you can check out the web site at www dot SAM-e dot com. It is considered very safe and effective for joint paint. Another natural remedy is Glucosomine and Chromium which is also over the counter.