Sulfasalazine and Minocycline,which one is better?

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New Member

Date Joined Dec 2012
Total Posts : 13
   Posted 4/18/2016 12:25 PM (GMT -6)   
My doctor has allowed me to choose between Sulfasalazine or Minocycline for my RA. I really need the opinions from anyone who has had experience with these 2 medicines. Please note that I am very sensitive with medicine and with food.



Elite Member

Date Joined Jul 2009
Total Posts : 14475
   Posted 4/18/2016 7:49 PM (GMT -6)   
Sorry, I can't help you. I'm allergic to both of them. :(
Lupus, RA, Fibromyalgia, Glaucoma, Asthma, Hypothyriodism, Sleep Apnea, Depression, Allergies, diabetes, and benign familia tremors

When life throws you lemons....
Pick them up and throw them right back at them! :))

Regular Member

Date Joined Mar 2013
Total Posts : 36
   Posted 4/21/2016 1:37 PM (GMT -6)   
I have been on Sulfasalazine for the last 6 months and it takes alot to get used to this medication. For 2 months I stayed so sick to my stomach and had to keep the belly full because you have to take it on a full stomach. It also took 5 months to work. It took all i had to get used to Sulfasalazine. Before this med I was on plaquenil but it quit working after 2 years. Drink alot of water because if you dont it will turn your skin orange and your stool will be orange too. So wish i could help with the Minocycline but havent had any experience with it and didnt know it is used for RA. Good luck, Constantpain

Veteran Member

Date Joined Jul 2015
Total Posts : 595
   Posted 5/3/2016 7:50 PM (GMT -6)   
I am not familiar with minocycline but I tried suflasalazine and it made me sick to my stomach. I had to stop taking it after 3 days. Can you take any of the biologic medications (ie, Enbrel, Humira, Remicade, etc.?) They seem to work pretty well.
Diagnosed with ulcerative colitis in 2005 and rheumatoid arthritis in 1998. On Remicade since 2005 for both diseases. For UC tried sulfasalazine, Lialda, colazal and others which made me ill. Started 50 mg. Imuran July 2015. Use Bentyl, peppermint oil capsules and Gas-X which all help with various UC symptoms during a flare.

Caregiver for mother with Alzheimer's Disease (for Alz. forum).

New Member

Date Joined May 2016
Total Posts : 5
   Posted 5/5/2016 7:20 AM (GMT -6)   
I've been on sulfasalazine for just over 3 months now with no side affects, however I can't say I've noticed it helps. I'm still on steroids to control my flare-ups, but it's till early days I suppose. Haven't heard of the other ones though. Hope this helps :)

New Member

Date Joined Dec 2012
Total Posts : 13
   Posted 5/10/2016 8:31 PM (GMT -6)   
Thank you very much for all the information you all gave me. I am trying Minocycline 50 mg for 2 weeks already, no side affects but no improving yet. Just having blood test this afternoon to see how my kidney doing. hope everything is ok. thank again.

Veteran Member

Date Joined May 2013
Total Posts : 548
   Posted 5/11/2016 7:05 PM (GMT -6)   
Hang in there, mino can take a while to work. I was on it for months and finally had to stop due to stomach problems but I know that some people have had it work well. Same with Sulfa. It took almost 6 months to kick in but once it did I was on it for a year or so and went into a remission that lasted for about another year.

Do yourself a favor and eat something with these every time. Take care of your stomach, after 20 years of RA and all kinds of NSAID's my stomach can't handle ibuprofen or aspirin at all. Let alone all those spicy foods I used to love.
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