I started Orencia IV 750 mg initial dose. After 4 days, all areas that were painful have intensified, worst on the base of my left thumb which I am now unable to use/move due to severe pain. I am waiting to call the rheumatologist this AM. The same thing happened when I took Enbrel sq 2 months ago and the same thing happened. All my pains intensified, worst on my right ankle, to point I could not walk on it due to pain. Anyone has thoughts on this? Has this happened to you?