Hi Carol. Thank you for posting! and welcome to HW. I currently take enbrel; I've been on it for about 3.5 months now. I have not experienced the side effect you were talking about (baking from the inside out), but I must say it does sound quite uncomfortable. I've read that headaches can be a side effect of enbrel. I have not had any side effects other than some injection site reactions and a few petachie here and there (which may not even be related to enbrel). Others on this board have been on enbrel a lot longer. also, you might want to call enliven services. This is the support services for enbrel users and is staffed by medical nurses to answer your questions. You can find the number on the enbrel website.