Hi Tiddly, I've been taking Enbrel for 4+ months now. I'll admit, it's not doing enough for my joints, but it really helps with energy. And it kicked in after about the 2nd or 3rd injection (2-3 weeks). That's why I'll probably add mtx in a couple of weeks (mtx increases the effectiveness of enbrel) instead of just ditching the enbrel. The increase in energy has been amazing; I hope that does the trick for you too.