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elcamino
Veteran Member


Date Joined Sep 2005
Total Posts : 1744
   Posted 7/21/2006 8:19 AM (GMT -7)   
For those of you taking MTX, or immuran for that matter, when did side effects first hit you?  I'm only taking 7.5mg of mtx a week for right now.  Rheumy said I need to ease into it.  I know I was a little nauseated last week when I took it, and wasn't hungry for a couple of days, but that was it.  Can you expect bad side effects at 7.5mg, or will they most likely come when rheumy increases the dosage?  It's not that I'm expecting bad side effects, but I'm going on vacation starting tomorrow after I take my second dose.  I will be out of town, so if I experience any bad side effects I'm not sure what to do, short of going to a local ER (which is not something I would want to do).  I'll still only be taking 7.5mg (tonight) this week.  Going in for bloodwork a week from Monday.
 
Elcamino
Current dx: Rheumatoid Arthritis
Suspected dx: UCTD/Early Lupus
Current Meds: Enbrel, Plaquenil, Aciphex, Ultracet, Zyrtec, Allavert-D, Zantac, Tylenol PM
Past Meds: Relafen, Vioxx, Mobic, Voltaren, Sulfasalazine, Entocort, Prednisone, Humira, Reglan


NelsonUK
New Member


Date Joined May 2006
Total Posts : 3
   Posted 7/21/2006 8:32 AM (GMT -7)   
Hi there
My father takes Methotrexate for rheumatoid arthritis he’s now on 10mg a week. He takes 5mg on Sunday and 5mg on Monday 24 hours later but he also takes 10mg of Folic Acid on Saturday 24 hours before starting the Methotrexate. This has all been supervised by his rheumatologist.
He takes the Folic Acid because it is supposed to help with the stomach upset but he still feels a bit groggy and has a “funny” head for a couple of days after taking the Methotrexate which last until about Wednesday.
Any change in medications or additional ones must be supervised by your rheumatologist as everyone is different and you are on other medications too.
Good luck
Best wishes - NelsonUK

erin.K
Veteran Member


Date Joined Mar 2005
Total Posts : 3148
   Posted 7/21/2006 9:48 AM (GMT -7)   

the Imuran @ 25mg caused no nausea or vomiting at all for me.  i took it with or without food everyday... didn't make a difference.

@ 50mg Imuran, after about 3-4 weeks at that dose, it depleted my WBCs further, caused nausea that lasted for about only 2 weeks.  now it's at the point where i think it only adds a little bit of exhaustion...but that could be from other crap i take or from RA and everything else.  oh and some hair loss & thinning.

                                   (((((((((BEST OF LUCK TO YOU!!!!!!!!!!))))))))))))


Active, Severe Rheumatory Arthritis. Crohns. AS. Chiari Malformation & Right Brain venous anomoly. Partial complex seizures. Emphysema. Rheumatic Lung & Heart. MVP and Tricuspid prolapse. Had Lymes disease for 10 years.
Meds: Humira 40mg Q 4 days; Pred 20mg prn; Pentasa 4G daily; Imuran 50mg; Dilaudid 4mg; Diazepam 5mg; Avinza 30mg; Reglan; Meclizine; LidoDerm; MiraLax & too many others.


elcamino
Veteran Member


Date Joined Sep 2005
Total Posts : 1744
   Posted 7/21/2006 10:01 AM (GMT -7)   

Thanks for the info.  I thought it would probably take 3-5 weeks before I felt any major side effects.  I took sulfasalazine (last fall) for 5 weeks before it lowered my blood counts.  And I know that 7.5mg is not that much.  I'm sure rheumy will increase it to 10mg, but not until mid-August when I see him again.  I pretty much have to monitor side effects myself 'til then.

Elcamino


Current dx: Rheumatoid Arthritis
Suspected dx: UCTD/Early Lupus
Current Meds: Enbrel, Plaquenil, Aciphex, Ultracet, Zyrtec, Allavert-D, Zantac, Tylenol PM
Past Meds: Relafen, Vioxx, Mobic, Voltaren, Sulfasalazine, Entocort, Prednisone, Humira, Reglan


curley
Veteran Member


Date Joined Mar 2005
Total Posts : 4305
   Posted 7/21/2006 12:42 PM (GMT -7)   
Hi,I'm not on imuran for right now but that may change.I'm not on Methotrexate either had to come off of it because I'm on 6mp and the two don't jive.When I was on methotrexate I was taking the shot form and reason being I have crohns and it was just to harsh on my gut.When I first stated taking Methotrexate it was about two month's before I noticed any different's.
Thanks
Curley......
a.k.a.Mela...........


yalinda
Veteran Member


Date Joined May 2006
Total Posts : 1179
   Posted 7/21/2006 2:44 PM (GMT -7)   
hi everyone!  back from the mountains of Utah..... elcamino, welcome to mtx? haha i started with 10 mg and the first few weeks got a little motion sickness feeling about 2 hours after taking it but then after the first maybe month i did fine.... i just got my dose increased to 15 mg and was able to skip the last dose while i was on vacation.  i asked if i could and my rhuemy said yes, plus he thought it best since i was increasing my doese to wait to see about any side effects while i was home and not away.... so tomorrow is my first 15 mg dose! (6 tabs) i hope i do not get sick?  but i have been good on the 10 with only fatique, which maybe due to the RA also?  good luck! and let me know how u do!  :-) ~*yalinda

elcamino
Veteran Member


Date Joined Sep 2005
Total Posts : 1744
   Posted 7/21/2006 4:18 PM (GMT -7)   

Yalinda, welcome back!  Wow--you started on 10 mg!  That's high.  That may be my highest, have to wait and see what happens.  I just took my weekly dose about an hour ago.  So far so good, but we're going on vacation to the beach tomorrow so I need to do some packing just in case I feel sick later.  Of course, if I feel sick, I can always blame it on mtx, and dh will pick up the slack :)

You know what freaks me out about mtx?  All of a sudden it's all over the news about people dying and what not?!?  I think most of the death are due to errors in dosing, though.  People don't understand the once/week dosing and may take it every day (eek).  Evidently, some doctors don't understand the dosing either (pretty scary thought).  My rheumy was very clear, though, that it was a once a week drug.  And since I already take enbrel once a week, 'tis no big deal to mtx once a week as well.  My husband just told me that another woman died from mtx--inappropriate dosing.  And I was reading this article that mentioned all of the people involved in making this drug safe for patients.  Don't forget the pharmacist, who can either make a dosing mistake, or catch a dosing mistake that a doctor has made.  For example, my insurance only authorizes medication for a month at a time (not 3 months like some other health companies).  As a result, my pharmacist gave me exactly 12 pills.  If he had given me 3 months at a time, I would run a greater risk of taking more than I should.  It would be easy to do.  Also, too many PCPs get involved in prescribing this drug, and they really shouldn't.  It should be left to the specialists.

 

Enough of a rant!  See you guys next week!!!!!!

Elcamino


Current dx: Rheumatoid Arthritis
Suspected dx: UCTD/Early Lupus
Current Meds: Enbrel, Plaquenil, Aciphex, Ultracet, Zyrtec, Allavert-D, Zantac, Tylenol PM
Past Meds: Relafen, Vioxx, Mobic, Voltaren, Sulfasalazine, Entocort, Prednisone, Humira, Reglan


yalinda
Veteran Member


Date Joined May 2006
Total Posts : 1179
   Posted 7/21/2006 4:41 PM (GMT -7)   
wow! i can only hope the rhuemy knows what he is doing?! i was increased because with the decrease in the prednisone the mtx was not doing enough? i am not on other drugs with it but the pred in hopes of gettin off that? gosh i looked into mtx online a while back and it has been used like since the 50's or 60's to tx RA..... i havent seen any of the bad stuff recently. please share if anyone has further info as to recent deaths? my hubby hates that i am on it! he is very concerned with long term chemos. but i told him all drugs will be long term as this is not going away real soon! i take it on saturday morning 6 pills now and hope all will be ok ???? i just know i need to get off the prednisone that too is bad stuff? i think sometimes i am danged if i do and danged if i dont...... any info please share , but i am limited because of HBP and kidney strain to some meds. thanks elcamino and have a nice trip i hope u feel great while u r away! ~*yalinda

elcamino
Veteran Member


Date Joined Sep 2005
Total Posts : 1744
   Posted 7/21/2006 5:46 PM (GMT -7)   
Yalinda,  I didn't mean to scare you!  10mg of mtx is perfectly standard; well within the normal range from what I've read.  I've simply read that most people start off with 7.5 mg and work their way up to 20mg, 10mg is still a little on the low side.  You can go much higher.  Personally, between prednisone and mtx, I'd take mtx hands down.  Prednisone is such a wonderful drug--I loved it when I was taking it--but it is a double-edged sword.  My mother took this drug off and on my entire life.  It can devastate your body in ways you can't even begin to know when you take it for years on end.  The awful weight gain and moon face are symptoms we all experience on it; osteoporosis, and even horrible damage to your GI system can also result.  There are probably other things the drug can do as well. 
 
That being said, it's a great drug as long as you are being closely monitored while on it.  I know in many cases, like my mom's, there was no alternative to being on the prednisone.  She could not take mtx because she had interstitial lung disease.
 
It sounds like you're doing just fine on 10 mg of mtx.  Most of the horrible side effects of mtx come with the higher doses used for chemotherapy.  The deaths I referred to earlier were because patients (and some doctors) didn't understand the dosing instructions and took more of the mtx than their body could handle.  No one, that I've learned of anyway, died of low dose mtx because of side effects, unless their doctor was not properly monitoring them.
 
Elcamino
Current dx: Rheumatoid Arthritis
Suspected dx: UCTD/Early Lupus
Current Meds: Enbrel, Plaquenil, Aciphex, Ultracet, Zyrtec, Allavert-D, Zantac, Tylenol PM
Past Meds: Relafen, Vioxx, Mobic, Voltaren, Sulfasalazine, Entocort, Prednisone, Humira, Reglan

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