Hey...sorry to be late here :) I lost my connection for awhile. With regard to acetaminophen, I think Europe and Canada are much more knowledgeable about this pain reliever and liver toxicity. It only takes one time to destroy your liver. One overdose with acetaminophen, and you can be on the list for a transplant. People most likely to do this are those that drink alcohol. The combination of the two is really bad.
El C, please stop the Tylenol PM! You can get the PM without the tylenol. Since the steroids and no sleep for me, I have been taking a generic (cheap) version of over the counter Unisom. The active ingredient is diphenhydramine hydrochloride. Hain't got a clue as to what that is, but it works better for me than Lunesta.
I also take Tramadol. I looked it up on a pharm site and it said each had 350mg of acetaminophen. One extra strength Tylenol has 500mg. I think you are fine with the Tramadol.
GEEZE, I just went to a pharm site and dayum! You guys have got to study the MTX side effects and interactions with other meds like NSAIDS!!! Are any of you losing hair (alopecia)?
MTX can also cause abnormal liver function tests. That is why I went there in the first place, to see if the med was hard on the liver. This is a very serious medicine, and if precautions are taken, probably a very good medicine.
Here is a linl to the info. Note the little tabs at the top of the page. You can get more info. I haven't even read the precautions and warnings...
Good day to all,
P.S. I just read the warnings for this medicine. If any of you can not click on the warning tab and read that page, please tell me. One of the better things it can do is cause damage to the liver.....I'm sorry but I would have to be persuaded by more than one doctor to take this medicine.
Post Edited (Aldo) : 8/1/2006 12:30:27 PM (GMT-6)
Hey RJ, thanks for the info. I've researched mtx through and through. I think I'm familiar enough with the side effects that I know it's a serious medication (I've managed to avoid it for the last year because I know too much about it)--haven't lost any hair yet. I imagine at the low doses we take of mtx, though, that the hair may thin, but not completely fall out as it would at the higher chemotherapy doses?
BTW, I have tried to take the pm without the tylenol and it has the same effect on me that alcohol does. It knocks me out initially, and then I wake up repeatedly throughout the night. It's the tylenol in it that keeps the aches and pains at bay, I guess? I suppose I could always ask my rheumy for a prescription for lunesta or the equivalent, but I figured if an OTC drug was doing the trick then why bother? Also, isn't lunesta habit forming?
Or perhaps I could take 2 additional tramadol (I only take 4/day and I can take up to 6) combined with the pm(without tylenol), but tramadol has acetaminophen in it so I don't know what good that would do.
you know...ya never think if this crap until it hits ya! but Rj you're right, overdose of Tylenol will land you with a likely case of severe liver failure and damage. no one is to take more than quantity 8 500mg tablets per day of acetamoniphen. so in short 4 Grams is the maximum. people that are over 75, bedridden, or who drink alcohol daily, have liver or kidney disease should reduce the maximum dose to 2 Grams per day.