Hi. Are you referring to prednisone? If so, I know it's a wonderful bridge drug, but not a great drug to remain on. Weaning off is probably for the best. Prednisone can certainly affect blood values. I know that when I was on sulfasalazine, my blood counts plummeted; one weekend of high dose prednisone and my blood values were in the normal range (literally, this was a Friday to a Monday). Several other drugs also affect blood values--how they affect them depends on which drug it is.
Current dx: Rheumatoid Arthritis
Suspected dx: UCTD/Early Lupus
Current Meds: Enbrel, Plaquenil, Aciphex, Ultracet, Zyrtec, Allavert-D, Zantac, Tylenol PM
Past Meds: Relafen, Vioxx, Mobic, Voltaren, Sulfasalazine, Entocort, Prednisone, Humira, Reglan