Enbrel and Congestive Heart Failure

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elcamino
Veteran Member


Date Joined Sep 2005
Total Posts : 1744
   Posted 9/13/2006 5:53 AM (GMT -7)   
In my own research I've run across several studies that have examined the role enbrel, and other tnf-inhibitors may play in congestive heart failure.  What I've learned so far is that it is possible that enbrel can negatively alter the course of congestive heart failure in patients who already have the condition.  I haven't seen anything indicating that enbrel actually causes congestive heart failure, but if you have documented chf, make sure your doctor knows that.  Here's a link to one of the study write-ups I've run across--there are lot of other studies as well.  http://www.indianjmedsci.org/article.asp?issn=0019-5359;year=2005;volume=59;issue=8;spage=363;epage=366;aulast=Gupta
 
It makes me wonder if that's what has happened with me.  Perhaps I had mild, undiagnosed chf prior to taking the tnf-inhibitors, and now that I've been on them for 8 or 9 months, the chf is getting worse.  I think I'll ask the pulmonologist this question next week.
 
Elcamino
Current dx: Rheumatoid Arthritis
Suspected dx: UCTD/Early Lupus
Current Meds: Enbrel, Plaquenil, Aciphex, Ultracet, Zyrtec, Allavert-D, Zantac, Tylenol PM
Past Meds: Relafen, Vioxx, Mobic, Voltaren, Sulfasalazine, Entocort, Prednisone, Humira, Reglan


Ducky
Veteran Member


Date Joined Mar 2005
Total Posts : 3199
   Posted 9/13/2006 8:47 AM (GMT -7)   
Wow Elcamino... that is something to really think about... I didn't know that... good luck and let us know what the doc says!
Confirmed Diagnosis of - Psoriatic Arthritis/Spondylitis/Graves Disease/GERD/Scoliosis/Hiatal Hernia/Graves Disease of the Eyes/Chronic UTIs
Current Meds -  Enbrel/Prevacid/Synthroid/Nitrofurantoin
Past Meds - Inderal/PTU/Prednisone/Voltaren/Feldene/Mobic/Cortisone and Steroid Shots
Additional Supplements - Multi-Vitamin/Bromelian/Acidophilus/Green Tea

razzle51
Veteran Member


Date Joined Jan 2005
Total Posts : 763
   Posted 9/13/2006 8:52 AM (GMT -7)   
Every medicene you take has risks
Syringomyelia T4-T10
Chiari Malformation
Decompression Surgery 1999
 
"Every day may not be good,
but there's something good in every day"
 
 
"Remember I'm pullin' for ya, we're all in this together" Red Green


yalinda
Veteran Member


Date Joined May 2006
Total Posts : 1179
   Posted 9/13/2006 9:26 AM (GMT -7)   
wow good research.... how ironic if it would be the embrel and not the mtx? keeping you as always in my prayers.... hope you get answers soon..... yalin

elcamino
Veteran Member


Date Joined Sep 2005
Total Posts : 1744
   Posted 9/13/2006 10:19 AM (GMT -7)   
Razzle, I realize that every medication has its risks, but the chf risk was never noted, or emphasized, in any of the information sheets I've received on enbrel.  These sheets always talk about the increased risk of infections, and of lymphoma, and certain blood disorders.  I've never read anything about chf, though?  I think if Enliven Services calls me (the enbrel cheerleader squad), I may ask them about this side effect.  Of course, even if I had known about it I would have taken the enbrel anyway, as I had no knowledge that I even had heart issues.
 
Elcamino
Current dx: Rheumatoid Arthritis
Suspected dx: UCTD/Early Lupus
Current Meds: Enbrel, Plaquenil, Aciphex, Ultracet, Zyrtec, Allavert-D, Zantac, Tylenol PM
Past Meds: Relafen, Vioxx, Mobic, Voltaren, Sulfasalazine, Entocort, Prednisone, Humira, Reglan


Ides
Forum Moderator


Date Joined Nov 2003
Total Posts : 7077
   Posted 9/13/2006 4:19 PM (GMT -7)   
Remicade has carried a warnign about "heart failure" for sometime, at least since before Novemner of 2004 when I began taking it. That said, I hope that the doctors can get to the root of your problem, elcamino!
CD, Ankylosing Spondylitis, peripheral neuropathy
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elcamino
Veteran Member


Date Joined Sep 2005
Total Posts : 1744
   Posted 9/13/2006 5:17 PM (GMT -7)   
Ides, my old friend. I've thought of you often in the past couple of months. You are always in my prayers.

I stand corrected--I just saw an enbrel commercial on tv. It clearly said that you should alert your rheumatologist if you've ever been treated for heart failure BEFORE taking enbrel. I guess I never noticed it before because it seems like an unlikely event with me.

I'm positive my doctors will figure out what my problem is. My chest is again very sore and congested, and I haven't taken mtx for 4-5 weeks now. In any case, I have a lot of support through my family and my church. I know that I won't be given anything I can't handle.

Elcamino
Current dx: Rheumatoid Arthritis
Suspected dx: UCTD/Early Lupus
Current Meds: Enbrel, Plaquenil, Aciphex, Ultracet, Zyrtec, Allavert-D, Zantac, Tylenol PM
Past Meds: Relafen, Vioxx, Mobic, Voltaren, Sulfasalazine, Entocort, Prednisone, Humira, Reglan


straydog
Forum Moderator


Date Joined Feb 2003
Total Posts : 13451
   Posted 9/22/2006 6:44 PM (GMT -7)   
El Camino, I am an old Remicade gal, I remember you on the cd forum. The CHF thing was put on Remicade because of the death related incident, the patient did not tell the dr he/she had CHF. This was in a trial. I am suppose to be scheduled for another echo, my gi is concerned I may be having right sided CHF. I am having horrible swelling in my legs & feet, they get so tight they feel like they will burst. I have had some weeping in the legs. When the fluid gets bad, I get this cough which is new for me. I don't usually go into CHF unless I am given a steroid....Susie


elcamino
Veteran Member


Date Joined Sep 2005
Total Posts : 1744
   Posted 9/23/2006 4:07 AM (GMT -7)   
Hi Susie,

I'm sorry to hear about your possible CHF. I believe I've read of a few incidents where remicade was implicated in CHF. But again, it did not cause CHF, but simply exaccerbated it in someone who already had it. So, you have CHF already, independent of the remicade? I didn't know that steroids could also exaccerbate CHF. I'll certainly pray that you don't have CHF, and perhaps it's swelling due to arthritis? do you have a rheumatologist?

It looks like I most likely don't have CHF, although still don't know what caused my abnormal finding on the x-rays. Pulmonologist thinks it may be related to acid reflux, which can lead to interstitial lung disease. Of course, ILD can eventually lead to CHF, so it's really one big, vicious circle, isn't it?

Feel better, ok?

Elcamino
Current dx: Rheumatoid Arthritis
Suspected dx: UCTD/Early Lupus
Current Meds: Enbrel, Plaquenil, Aciphex, Ultracet, Zyrtec, Allavert-D, Zantac, Tylenol PM
Past Meds: Relafen, Vioxx, Mobic, Voltaren, Sulfasalazine, Entocort, Prednisone, Humira, Reglan


missie1227
Veteran Member


Date Joined Nov 2005
Total Posts : 751
   Posted 9/29/2006 8:13 AM (GMT -7)   
el- waht exactly is ILD anyways...sicne i have gerd really bad i may be at risk for this without even knowing it...can you tell me some of the sympotms of ILD?

9-02 crash w/ C-5-6-7 anterior/posterior fusion in neck w/11 screws and 4 metal plates. multilevel HNP at T & L section. FMS, PA in dec 05. on SSDI after 2.5 yr wait. sezuires, CTS, IBS ( C & D). norco, xanax, predisone shots. i dont know what else is wrong with me and neither does anyone else!!!


elcamino
Veteran Member


Date Joined Sep 2005
Total Posts : 1744
   Posted 9/29/2006 8:32 AM (GMT -7)   

Missie, ILD, interstitial lung disease, is a broad category including over 100 different interstitial lung diseases.  Symptoms are usually very vague and nondescript (e.g., episodic shortness of breath, cough, etc....), but sx will also differ depending on which ILD a person has.  I think the only sure way to tell is to go to a pulmonologist (if you have shortness of breath and/or cough) and have some tests done.  The preliminary tests are likely to show nothing, but at least you will have established a baseline.

 

Elcamino


Current dx: Rheumatoid Arthritis
Suspected dx: UCTD/Early Lupus
Current Meds: Enbrel, Plaquenil, Aciphex, Ultracet, Zyrtec, Allavert-D, Zantac, Tylenol PM
Past Meds: Relafen, Vioxx, Mobic, Voltaren, Sulfasalazine, Entocort, Prednisone, Humira, Reglan


istone
Regular Member


Date Joined Nov 2006
Total Posts : 77
   Posted 11/29/2006 11:07 AM (GMT -7)   

hi

i would like to inform u that i dont have any dx for 1 year i have pain in my all my joints

all tests came negative. but i know is on immune system . may i ask u how u find a support from your churche? did u find a good rheumy? i consulted so many and were unable to find out what i have. i have already joints damage and i feel so terrified to get RA cos i know is so terrible and i wouldnt handle these medicine for RA.

could u help me pls to give some advice what to do im alone in my pain.

regards

iris

elcamino said...
Ides, my old friend. I've thought of you often in the past couple of months. You are always in my prayers.

I stand corrected--I just saw an enbrel commercial on tv. It clearly said that you should alert your rheumatologist if you've ever been treated for heart failure BEFORE taking enbrel. I guess I never noticed it before because it seems like an unlikely event with me.

I'm positive my doctors will figure out what my problem is. My chest is again very sore and congested, and I haven't taken mtx for 4-5 weeks now. In any case, I have a lot of support through my family and my church. I know that I won't be given anything I can't handle.

Elcamino


erin.K
Veteran Member


Date Joined Mar 2005
Total Posts : 3148
   Posted 11/29/2006 11:37 AM (GMT -7)   

hey el...i just wanted to add a quickie before i head off, but i truly feel that Enbrel, Humira and Remicade and even prednisone (in my own personal opinion) causes or triggers some sort of lung/edema/breathing issues for people who have an underlying lung or predisposition to a lung problem to begin with.

despite getting costochondritis & pleurisy....ever since i've been on the TNFs and steroids and bios and antirheumatics...like yourself, there began the issues of lung and heart problems. 

 now, whether the heart & lung conditions is totally from inflamation related damage from RA that hit the lungs & heart (because all of our inflammation with RA can scar the lung tissue & heart valves in some cases anyway) or is it the effects of the meds???????  that i have no clue. confused

i do know that i de get an exacerbation of shortness & difficulty breathing, eating, talking when on the TNF and bios. and with any chemotherapy...it can throw a person into CHF, so Remicade i can understand right away.

yeah...you've got one hellofagood point here.

it could be the same as their waver on the whole..."it may trigger any underlying CNS disorder like MS, blah blah blah...or activate TB, etc etc etc."  funny...it isn't clearly stated in the patient education from a few years back....i did read it in my nurses drug reference  guide however...there they list the CHF.

NEVER A DULL MOMENT!

take care El.

erin

 


Active Severe Rheumatory Arthritis. Crohns Disease. A.Chiari Malformation & right brain venous anomoly. Partial Complex Seizures. MVP & Tricuspid Valve Prolapse. Rheumatic heart & lung. Previous Lymes Disease for 10 years.
Meds: Remicade infusions Q3 weeks; Intra-articular knee injections; Imuran; Mesalamine; Prednisone tapering from 120mg; Meclizine; Reglan; LidoDerm; Diazepam; Restaril; Dilaudid; Avinza and too many others. 


Swanfleweast
Regular Member


Date Joined Nov 2006
Total Posts : 147
   Posted 11/29/2006 7:01 PM (GMT -7)   
I'll I know is when I started the enbrel in August 06, I ended up with pleurisy, very painful, very short of breath...basically through me into a bad flare, both RA and Fibro, and had to have an echo done. Now I am seeing a cardiologist tomorrow. They want to discuss results in person. HMMMN. Hopefully it's nothing..I never had heart or lung problems other than the normal bronchial asthma when a I get a bad cold. And I have had five infections in the last three months. Could be just the RA but ya never know...After that I tried Humira and got a rash and very bad injection site reaction. So now a year later still waiting to be treated for the RA.
Lori
Fibro, RA, IBS, Anxiety, insomnia
 
Meds:Serax 10mg, Mobic 15mg, Prednisone 15mg, Prilosec 20mg, Vicodin 5/500, Flonase, Calcium and magnesium
 
Currently-Septra, Mupirocin 2% for the nose
 

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