I've been on injectible MTX (.7 mls = 17.5 mgs, I think) for 2 years (first with Enbrel, now with Remicade). We are upping my dosage in December. It has really helped with my RA (in my hands). Other than some nausea and hair thinning, I really didn't experience much in side effects. We solved that by upping my dosage of prescription strength folic acid. I'm at 2 mgs daily and have been there for 1-1/2 years. If you do decide to do the MTX, you must have a prescription for folic acid. OTC folic is just not strong enough (it's measured in mcg, not mg's) and you'd have to take quite a bit! I inject my MTX right before bedtime, so if I experience anything, I'm already asleep and don't know it!
Also, don't forget the regular blood tests - those are just as important as the folic acid. My rheumy gives me permission to drink - on very special occasions and then it's only a glass of wine, maybe 2. If I want more, then I'm not to take my shot for the week -- so far, I haven't indulged in more than 1 glass of wine and it's quite rare when I have one!! My blood tests have all come back just fine.
Hope this helps and good luck with your decision.
"My "Trifecta" - CD, AS & RA...
Co-Moderator Crohn's Forum