Lori, it sounds like you have a tricky situation here. I'm sorry to hear about your problems with meds. Have you tried prednisone before? It's a great anti-inflammatory, and certainly has some negative side effects, but none as bad as what you've described with mtx and the biologics. Many people use NSAIDS for RA, like Mobic. Unfortunately, NSAIDS do not modify the RA process and they can be toxic when used long term. Prednisone may be a short-term option. There are also 3-4 other DMARDS (remicade and a couple of new tnf-inhibitors--I forgot their names) that you can also try. Also Kinaret. My rheumy said everyone reacts to the tnf-inhibitors differently, and you don't know what's going to work for you until you try them all. Humira didn't do much for me; enbrel is a bit better but not completely there without the mtx. If these combos don't work, I will probably try kinaret, and then graduate to the IV drugs like remicade and others. There is certainly something out there for you; don't give up. Let us know what you decide to do.
Current dx: Rheumatoid Arthritis
Suspected dx: UCTD/Early Lupus
Current Meds: Enbrel, Plaquenil, Aciphex, Ultracet, Zyrtec, Allavert-D, Zantac, Tylenol PM
Past Meds: Relafen, Vioxx, Mobic, Voltaren, Sulfasalazine, Entocort, Prednisone, Humira, Reglan