Hi Theresa, don't feel bad about asking questions. It's the people who don't question that you need to worry about. With respect mtx and illness, like Yalinda, I'm not qualified to advise you what to do. I can share with you, however, what my strategy so far has been. I've been taking enbrel for 8 months, and recently started mtx. Went to primary last week and was dx with a sinus infection. I started antibiotics. I asked her point blank if I should continue with the enbrel and mtx. She said she saw no reason not to because I didn't register a fever (over 101 degrees) in her office. I did do my enbrel injection on Saturday, and everything is fine. I plan on taking my mtx on Wednesday. I won't take it, or I will call my rheumy and ask, if I still feel really bad. I think you really should ask your doctor about this. I've been on antibiotics for 4 days now, and I don't feel much better than before I started them. Enbrel and mtx could possibly slow down the recovery period. Mtx lowers your WBC, so it could take longer for your body to fight infections. I'm considering the flu shot for this year--I have young children as well, who are currently in preschool and bring home all kinds of germs. In fact, I'm sure I caught a cold from them that evolved into a sinus infection for me.