I was on Remicade for about 20 months - it did wonders for my psoriatic arthritis immediately. Within 48 hours of my first infusion, a severe psorisis flare cleared up. After a couple of infusions, my joint pain was almost nonexistant.
At first, I had no problems...other than maybe an itchy throat during the infusion. The problems gradually got worse. I don't recall getting the shakes, however. I took benedryl and tylenol as a premed. Eventually, near the end, I started taking the steroid premed and zyrtec (an RX'd allergy med.) I started getting more severe reactions like itchy skin, swollen eyes that would last for days afterwards, and eventually the infusions would cause a severe flare. My immune system broke down I had constsant infections (pneumonia, etc.) and my liver went toxic. I stopped it and it took a year before my health started to balance back out.
I gave it my best - didn't want to stop the remicade until I was absolutely sure.....it was so sad to stop because it had worked so well, but in the end it was causing more harm than good.
I don't want to scare you to stop unless you are sure that is the right thing to do, but yes, your body can reject it or have severe allergic reactions. On the other side, I know/spoke to quite a few people taking it and I'm the only one who couldn't tolorate it. Good luck. *****