Neurological symptoms after starting Mercaptopurine?

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Veteran Member

Date Joined Mar 2005
Total Posts : 3148
   Posted 1/27/2007 9:49 AM (GMT -6)   
Hey all,
Has anyone experienced this?
Started pretty much immediately...the first 24 hours in taking the 1st dose of mercaptopurine.  First thing was vision changes.  Sorta like when the eye doc dilates your eyes? A little traily-like too?
Numbness in the feet/hands. Pins n' needles type feeling in arms & legs.
And the weirdest thing so far...feels like an ice cube is running  down & up your arm? (right arm)
So I don't know if I'm just on TOO MANY MEDS...and maybe there's an ineraction somewhere, or if this is a common thing.
Sometimes I feel I don't know when to open my mouth about something or to ignore it!!!!
Any experience is much appreciated. Thanks. 
Arthritis Forum Moderator
Active Severe Rheumatory Arthritis. Crohns Disease. A.Chiari Malformation & right brain venous anomoly. Partial Complex Seizures (under control!). MVP & Tricuspid Valve Prolapse. Rheumatic heart & lung. Previous Lymes Disease for 10 years.
Meds: Remicade infusions 300mg Q3weeks; Intra-articular knee injections; Imuran; Arthrotec; 6MP; Mesalamine 4Grams; Prednisone; Entocort; Meclizine; Augmentin; Reglan; LidoDerm; Diazepam; Restaril; Dilaudid. 

Regular Member

Date Joined Dec 2006
Total Posts : 74
   Posted 1/27/2007 10:10 AM (GMT -6)   
Hey Erin,

I just have to say, that is a pretty serious Medication they have you on, I went on google, then on medline plus, and the symptoms that you are expereincing are not on the list, soo its possible that you are having a Drug interaction....SOOO PLEASE LET your DOCTOR, know all the side effects that you are going thru..

Here's is the website that i was reseraching 4 you....

I hope you Feel Better..and let us know how you are DOing...


Veteran Member

Date Joined Mar 2005
Total Posts : 3199
   Posted 1/27/2007 4:51 PM (GMT -6)   
Hey there.. I found this on Wikipedia... Which doc put you on this?
Some of the adverse reactions of taking Mercaptopurine might include diarrhea, nausea, vomiting, loss of appetite, stomach/abdominal pain, weakness, skin rash, darkening of the skin, or hair loss. Serious adverse reactions include mouth sores, fever, sore throat, easy bruising or bleeding, pinpoint red spots on the skin, yellowing of eyes or skin, dark urine, painful or difficult urination. Unlikely but serious side effects include: black or tarry stools (melena), bloody stools, and bloody urine.

Symptoms of allergic reaction to Mercaptopurine include rash, itching, swelling, dizziness, trouble breathing.

Mercaptopurine causes myelosuppression, suppressing the production of white blood cells. It may be toxic to bone marrow. Weekly blood counts are recommended for patients on mercaptopurine. The patient should stop taking the medication at least temporarily if there is an unexplained, abnormally large drop in white blood cell count, or any other blood count.

Patients who exhibit myelosuppression or bone marrow toxicity should be tested for Thiopurine methyltransferase (TPMT) enzyme deficiency. Patients with TPMT deficiency are much more likely to develop dangerous myelosuppression. In such patients it may be possible to continue using mercaptopurine, but at a lower dose.

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Veteran Member

Date Joined May 2006
Total Posts : 1179
   Posted 1/27/2007 5:51 PM (GMT -6)   
be careful! call the pharmacy if u cant get a docon the weekend? hey u want to meet at the er and have a party? lol

Regular Member

Date Joined Nov 2006
Total Posts : 450
   Posted 1/27/2007 11:08 PM (GMT -6)   
Erin, look in the mirror. Are your pupils the same size? Are they reacting normally to light/dark?
You need to go to the ER sweety.
God Bless!!!!!~Savvy~ 
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Forum Moderator

Date Joined Nov 2003
Total Posts : 7055
   Posted 1/27/2007 11:46 PM (GMT -6)   
Why are you taking BOTH Imuran and Mercaptopurine? Or did you just not update your signature? Imuran metabolizes into Mercaptopurine so the potential for overdosage if you are on both is great.
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Veteran Member

Date Joined May 2006
Total Posts : 1179
   Posted 1/28/2007 10:09 AM (GMT -6)   
erin how r u? r u ok? u have us al worried....... did u stop anymeds? still have symptoms? go to er? let us know mama yalin
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