MTX injections anyone?

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Veteran Member

Date Joined Sep 2005
Total Posts : 1744
   Posted 2/26/2007 9:30 AM (GMT -6)   
I was wondering how many of you are on the mtx injections, as opposed to the pills.  I've been experiencing a great deal of upper and lower GI issues since starting the mtx.  MTX works great on my joints, but am I destroying my GI tract with it?  I've taken aciphex for years, supplemented with zantac 150 every night.  Nowadays, I find myself popping tums and extra zantac to take care of the same problem.  Lower GI issues too, for a few days after my mtx dose.  Lower GI is not as troublesome, though, as upper GI stuff.  I know that mtx is available in injection form and was wondering what the qualifying criteria are for the injectables.
Thanks for any info.
Current dx: Rheumatoid Arthritis
Suspected dx: UCTD/Early Lupus
Current Meds: Enbrel, Plaquenil, Aciphex, Ultracet, Zyrtec, Allavert-D, Zantac, Tylenol PM
Past Meds: Relafen, Vioxx, Mobic, Voltaren, Sulfasalazine, Entocort, Prednisone, Humira, Reglan

Veteran Member

Date Joined Mar 2005
Total Posts : 3148
   Posted 2/26/2007 10:24 AM (GMT -6)   
I think you qualify.
I may be mistaken...but I "think" it's just a matter of choice when it comes down to it. Any doc in their right mind if they have a pt. who can't tolerate oral forms would be crazy not to let you do the injectable MTX.
Craig takes MTX shots...HEY CRAIG!!!!! HOW DID YOU START?????
Arthritis Forum Moderator
Active Severe Rheumatory Arthritis. Crohns Disease. A.Chiari Malformation & right brain venous anomoly. Partial Complex Seizures (under control!). MVP & Tricuspid Valve Prolapse. Rheumatic heart & lung. Previous Lymes Disease for 10 years.
Meds: Remicade infusions 300mg Q3weeks; Intra-articular knee injections when needed; Mercaptopurine 50mgQD plus 75mg weekly; Mesalamine 4GramsQD; Prednisone 20mgQD mantainance; Entocort 9mgQD; Meclizine; Augmentin; Tigan 300mg; Reglan; LidoDerm Patches; Diazepam 5mg for AS back spasms; Restaril; Dilaudid 4mg tabs for pain. 

Veteran Member

Date Joined Dec 2005
Total Posts : 1782
   Posted 2/27/2007 11:46 PM (GMT -6)   
I originally was on oral mtx, but it really made the nausea side effect much worse (as well as the hair loss), especially since we kept increasing the dosage. I talked to my rheumy about switching to the injectible and the next thing I knew, I'm giving myself weekly injections to supplement my Enbrel (when I was on it). Haven't had any stomach issues since and my side effects have disappeared as well. I'd definitely ask for the switch - certainly can't hurt.

Good luck!

p.s. almost forgot - we haven't increased my dosage in over 1-1/2 years either. I seem to tolerate the dosage (.7 ml = 17.5 mgs) quite nicely.
"My "Trifecta" - CD, AS & RA...

Co-Moderator Crohn's Forum

Remicade every 6 weeks, Methotrexate weekly, Folic Acid daily

Regular Member

Date Joined Apr 2005
Total Posts : 191
   Posted 2/28/2007 9:04 AM (GMT -6)   
I've been on MTX injections for over a year, and have recently moved to oral. I don't think there is any reason why you can't use one form or the other, depending on your situation.

The MTX injections were easier than the old Enbrel, before SureClick, but pills are easier than both.

I hate being on any of the drugs ... Craig
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