I guess my rheumy is a bit different than others. He started me on enbrel (actually, it was humira), but then I was having IBD symptoms at the same time and he knew that a tnf-inhibitor would take care of those sx as well. Technically, I started on sulfasalazine and had a severe allergic reaction to the sulfa. Then I started on Humira. I wasn't getting any results a couple of months later, so I started on the enbrel. Even then, I didn't get any results until I was on it for almost 6 months--it's a great drug, but I still added mtx to it (recently). I should also say that my rheumy added plaquenil to the enbrel after I had been on enbrel for about 2-3 months. I never felt any different with the plaquenil, but my rheumy continues to leave me on it--I gather it's a subtle drug. about a month ago, I was taken off the enbrel for infection reasons, and I can tell you that I definitely feel the difference. I am much more stiff and sore than I have been. On enbrel and mtx, I felt almost completely normal. MTX and the plaquenil, alone, just aren't doing that, although they are doing something 'cause I'm certainly in the worst shape I've been prior to taking any DMARDs.
Once you get over the injection idea, enbrel (or any of the tnf-inhibitors) are not that bad. Enbrel made a huge difference in me, and I may go back on it one day. If you have any IBD issues, a tnf-inhibitor is definitely the way to go.
Best of luck to you! I hope enbrel makes as big a difference in the way you feel as it has done for me.