New Meds?!? Cytotech/COX2?

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erin.K
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Date Joined Mar 2005
Total Posts : 3148
   Posted 4/16/2007 7:07 PM (GMT -7)   
redface  i am beat! loooong Remicade day.
"otay" so my GI dude paid me a visit during my infusion today...we're taking about finding a "sister" drug to Arthrotech.  obviously the Arthrotech is totally outof the question as it's becoming dangerous for me with the bleeds.
 
he's giving me the OK to go on an NSAID....which i shoudn't theoretically do due to the Crohns....but the RA trumps the CD.
 
has anyone been on Cytotech? that's what he suggested. BUT...i disagree because i think the misoprostol is the agent that's CAUSING the uterine bleding (or wherever it's coming from up there) eyes
now Volteren (plain Diclofenac) was my suggestion.  but he thinks the plain diclofenac would cause too much Crohns uspet.

confused i'm stuck! confused

aaaargh.

his 2nd opinion would be for me to try again another COX2...those (i have been on all of them) they cause justrectal bleeding...but not the tremendous "labor" like pains & vaginal bleeding like the Arthrotech did.  he thinks perhaps a COX2 at a bigger dose than i was on in 2001.

anyone ever in a similar situation with these meds?

what do ya think?  i've got nothing to lose...so any opinions & past experience with these meds would be appreciated.

mad  i just don't wanna take prednisone all the time anymore mad

stuck in a pill dilemma.....erin


Arthritis Forum Moderator
Active Severe Rheumatory Arthritis. Crohns Disease. A.Chiari Malformation & right brain venous anomoly. Partial Complex Seizures (under control!). MVP & Tricuspid Valve Prolapse. Rheumatic heart & lung. Previous Lymes Disease for 10 years.
Meds: Remicade infusions 300mg Q3weeks; Intra-articular knee injections when needed; Mercaptopurine 50mgQD plus 75mg weekly; Mesalamine 4GramsQD; Prednisone 10mgQD mantainance; Entocort 9mgQD; Meclizine; Augmentin; Tigan 300mg; Reglan; LidoDerm Patches; Diazepam 5mg for AS back spasms; Rozerem 8mg; Dilaudid 4mg tabs for pain. 


elcamino
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Date Joined Sep 2005
Total Posts : 1744
   Posted 4/17/2007 4:21 AM (GMT -7)   

Erin--I sure hope you get your RA under control soon, without aggravating the cd!  I have never taken cytotec (or arthrotec either for that matter), but I have been on voltaren.  It worked wonderfully--but it immediately caused the most awful lower GI cramping I've ever had.  I even played around with it--took it for a couple of days, and did without.  Without question, it was the culprit in aggravating my GI issues, whatever they may be.  I would listen to your GI--don't take the voltaren.  I've tried a couple of cox2s--they did nothing for me, and ended up causing some GI issues anyway.  You can always try the cytotec, and stop it immediately if you start bleeding.  Do your GI doctor and rheumy coordinate at all?  It would seem that, in your case, that might be important.

Elcamino


Current dx: Rheumatoid Arthritis
Suspected dx: UCTD/Early Lupus
Current Meds: Enbrel, Plaquenil, Aciphex, Ultracet, Zyrtec, Allavert-D, Zantac, Tylenol PM
Past Meds: Relafen, Vioxx, Mobic, Voltaren, Sulfasalazine, Entocort, Prednisone, Humira, Reglan


erin.K
Veteran Member


Date Joined Mar 2005
Total Posts : 3148
   Posted 4/17/2007 9:23 AM (GMT -7)   
eyes  hmmm?  thanks El for the input.
ah hah...so when you took Voltaren, did it cause like massive "D"? 
at 1st...the Arthrotec just had me on the bowl all day (and i mean 18 hours) but no cramps...just going going going.  THAT I DID NOT MIND...because at least the joint pain was better.
 
when this bleeding started to happen...that was unbearable.  literally on the floor curled up in a ball IN PAIN...with serious contractions it felt like.  the misoprostol (the Cytotec) even though it's better for the gut; he said would most likely be doing that because it does cause abortion & it can cause the uterus to shed (and rupture even).
 
i dunno...i don't think i really want to experience that again.  after "having slept on it" last night...i think i'd rather shoot for trying Voltaren.
 
i realize i am not in a win-win situation.  if i take one thing, another problem will act up. 
 
yeah i agree El...when i was taking Celebrex (i was on Bextra, VIOXX, Mobic too...) they really did NOTHING.
 
my GI & Primary doc talk to each other basically every day because of hospital rounds; and my GI has  talked to my rheummy twice in the past. 
i'm pretty good at being the "middle man" between my rheummy & GI.
 
i know what's going to happen...they're going to be like "well what one do YOU want to try".  oy.
 
we shall see.  thanks again.  

elcamino
Veteran Member


Date Joined Sep 2005
Total Posts : 1744
   Posted 4/17/2007 11:49 AM (GMT -7)   

No, Voltaren did not cause D for me, but the cramping was unbelievable.  Very, very painful.  Of course, with your bleeding issues that would be of more concern (JMHO).  I simply don't like any NSAIDS, and as tempting as it would be to take one for the arthritis, I haven't been that desperate yet.  Wouldn't you think that they would have made prednisone safer by now?  Or at least with fewer side effects.  Personally, I love that drug, but I've never had to take it long term.  My mom did, so I've seen firsthand what it can, and does according to my rheumy, do to everyone who takes it long term.  You cannot escape the side effects.  I'd rather stick to the chemotherapy than switch over to prednisone.  Of course, I'm not in the pain that you're currently in.  How do you feel now, after the infusion?  I've heard that the first week or so after an infusion is pretty good for most who take remicade.

Feel better,

El


Current dx: Rheumatoid Arthritis
Suspected dx: UCTD/Early Lupus
Current Meds: Enbrel, Plaquenil, Aciphex, Ultracet, Zyrtec, Allavert-D, Zantac, Tylenol PM
Past Meds: Relafen, Vioxx, Mobic, Voltaren, Sulfasalazine, Entocort, Prednisone, Humira, Reglan


erin.K
Veteran Member


Date Joined Mar 2005
Total Posts : 3148
   Posted 4/17/2007 1:45 PM (GMT -7)   
smurf  hey el, you're the best...thanks for writing.
yeah i remember you telling us about your mom.  thanks for sharing your opinions with me....it's helped (even though i may still flip a coin in the air to decide, lol)
i wish that Advil, Naproxen or Ibuprofen helped my joints, i would just go on that.  but i guess they are not strong enough to help the RA pain. 
 
ah geesh, well i hope people  DO have relief the 1st week of the Remicade infusion.
 
yesterday was torture, pain was a 10+ for the joints; during the infusion the RNs had to pack me with ice bags the joint pain was so bad.
eyes  the only immediate relief i get is from the IV steroids. 
last night from 12 am till 2am i spent on the pot...from the Remicade (or the other meds i get) i come down with "post-infusion "ills""  feels like a stomach flu...cramps & "D" all night.
today?  nausea beyond belief. been taking Benadryl, Tigan, Prevacid all day to try to help ease the nausea.
my shoulders are a 10+ in the joints still...can't even lift them to wash my face, shower or put my hair up.  {i can type with my left hand however tongue }
 
i feel i do get a few "better" days the week of the Remicade.  they happen like the 4th & 5th day after.  since Oct. 9th (1st treatment) nothing positive has occured in relation to the RA.  it has helped the Crohns i think more than anything.
 
i have to keep myself grounded.  i do have expectations but i can't let myself get too saddened if they don't happen.
having already been on Enbrel, Humira, & now Remicade...i'm not responding the way i had wished to any of them.
the RA is WORSE when i do go off of them so they must do "something".
 
my docs are all aware and they make sure that i'm aware that my case of RA is a bit out of the ballpark.  it might be one of those RA cases where all treatments fail, not bringing about a remission or providing too much relief.
 
i'll stay on the biologics because i feel that even though the RA's still progressing ON the chemotherapy...i think it would progress even FASTER off of them.
 
me too...i do love pred in that it works beautifully...but i need to be on something DAILY, and the last thing i want is to be on pred daily (i don't need to tell you that, you're al too familiar) & then i'm stuck with my body NOT MAKING IT's OWN STEROIDS and screwing up my adrenal system. eyes
 
so far i've been in bed all day, really dizzy, weak...plus everything else on top of that.
it's just VERY hard.  i oh so wish i had received treatment for this 10 years ago.
 
i'm surprised i'm not THAT depressed! LOL.  my winning trait is my coping abilities, thank God!
 
thanks El & all those who have listenend to my rant n' rave.
will be keepin' ya posted. :-) erin
Arthritis Forum Moderator
Active Severe Rheumatory Arthritis. Crohns Disease. A.Chiari Malformation & right brain venous anomoly. Partial Complex Seizures (under control!). MVP & Tricuspid Valve Prolapse. Rheumatic heart & lung. Previous Lymes Disease for 10 years.
Meds: Remicade infusions 300mg Q3weeks; Intra-articular knee injections when needed; Mercaptopurine 50mgQD plus 75mg weekly; Mesalamine 4GramsQD; Prednisone 10mgQD mantainance; Entocort 9mgQD; Meclizine; Augmentin; Tigan 300mg; Reglan; LidoDerm Patches; Diazepam 5mg for AS back spasms; Rozerem 8mg; Dilaudid 4mg tabs for pain. 

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