I took enbrel for 8-9 months. Didn't have any very serious side effects. At first, I got sick a bit more than usual, but then you are suppressing your immune system with any of these drugs. Enbrel works--it took a while for it to kick in for me (5=6 months), but was well worth it in the long run. I was taken off it because I may have had latent tb (probably do not have tb, but I'm being treated for it anyway), which enbrel (and other tnf inhibitors) is not too good for. I must say that I do miss enbrel; the combination of enbrel and mtx made me feel 100% normal!
Best of luck to you,
P.S. make sure you get a tb test done before trying the enbrel.
Current dx: Rheumatoid Arthritis
Suspected dx: UCTD/Early Lupus
Current Meds: Enbrel, Plaquenil, Aciphex, Ultracet, Zyrtec, Allavert-D, Zantac, Tylenol PM
Past Meds: Relafen, Vioxx, Mobic, Voltaren, Sulfasalazine, Entocort, Prednisone, Humira, Reglan