I have been on MTX for 6 months. When I first started taking it, I did feel GROSS and so tired, I thought I wouldn't make it. After 1 month, I asked to be put on the injectable type which has been MUCH better as far as the GI symptoms are concerned. I also take 3 folic acid tablets/day except on the day I give myself a shot. I am not getting better like my rheumatologist hoped I would, and since I took Sulfasalazine earlier this summer and it made me SICK LIKE I HAD THE FLU PLUS NO APPETITE, he is going to try me on Humira. Evidently, you have to go through these various drugs to show the insurance company that you tried the inexpensive drugs first. I know how miserable you are. I am 48 and lately, I feel 78, and I can't imagine what it will be like when I am much older! Hang in there and try the injectable MTX (it DOES not hurt). You might find that not having it on your stomach will make it much easier to take.