Methotrexate/Remicade and Loss of Libido

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New Member

Date Joined Aug 2007
Total Posts : 1
   Posted 8/3/2007 10:03 AM (GMT -6)   
Hello Everyone,
We are new to this site. Glad we found it.  So, here is the question.  I have been experiencing a loss of libido since I started taking both of these drugs.  Not sure if it is one of them, both of them, or none of them.  Is this a side effect of these drugs?  If so, what can I do?  The medication has been great for my RA  but my husband and I are wondering how to deal with this side effect.  Thanks.

Veteran Member

Date Joined Mar 2005
Total Posts : 3199
   Posted 8/3/2007 12:58 PM (GMT -6)   
Hey there mtm.. welcome to healing well... So very sorry it is under these conditions.. Actually yes, one of the side effects of Methotrexate is reduced libido and even impotence in men.. Have you talked to your rheumy about it? He may be able to give you something to help with that.. I am assuming the Remicade is long term, is the Methotrexate going to be long term as well? Hang in there and keep us posted..
Moderator of Arthritis Forum
Confirmed Diagnosis of - Psoriatic Arthritis/Spondylitis/Graves Disease/GERD/Scoliosis/Hiatal Hernia/Graves Disease of the Eyes/Chronic UTIs
Current Meds -  Enbrel/Prevacid/Synthroid/Nitrofurantoin
Past Meds - Inderal/PTU/Prednisone/Voltaren/Feldene/Mobic/Cortisone and Steroid Shots
Additional Supplements - Multi-Vitamin/Bromelian/Acidophilus/Green Tea

Regular Member

Date Joined Jul 2005
Total Posts : 393
   Posted 8/3/2007 7:35 PM (GMT -6)   
Just my experience...I never experienced a loss of libido on Remicade. I currently have the same problem but I think mine is from the Prednisone or my antidepressant.

Maybe its the methotrexate? careful..Ive heard that drug causes some long term sideeffects

Yesterday I dared to struggle. Today I dare to win.

 Diagnosed with severe Crohn's colitis in May 2005. I deal with daily arthritis ALL over my body, cystic acne, & fibromyglia. Have taken Imuran, Remicade, TPN, Colozal, Entocort, Flagyl, PamineForte, Cipro, Dicyclomine, Prednisone, Asacol, Prevacid, and the list goes on. Taking low amounts of Pred now & 3600mg of Asacol currently...Can't wait till I can get back on Remicade, my miracle drug!

Regular Member

Date Joined Sep 2007
Total Posts : 26
   Posted 9/25/2007 12:07 PM (GMT -6)   
Hello mtm,
I am a new member of the forum too. Have been on methotrexate, prednisone and plaquenil, etc. for about 5 years now. Guess it depends on where your priorities are. I experienced much more loss of libido before these drugs began to 'check' my pain and make it more manageable for me. However, not as amorous as I once was. Of course am a lot older than I once was.

Our lives (spouse) are so full that this has not been a serious problem for us. If it is for you, seek help.
Wish you success with this.


UC Fighter
Regular Member

Date Joined Oct 2007
Total Posts : 89
   Posted 12/20/2009 11:45 AM (GMT -6)   
Oh, this isn't good news. I've been on it for 3 weeks at 1ml per week. Perhaps the dosage matters too. I'll have to keep an eye on this one.
 Current Rx:
15mg Prednisone / day
1 Acidophilous 2x/day
3 400mg Sulfasalazine, 2x per day
1ml Methotrexate, 1x per week
Folic Acid Rx

peggy baggins
Regular Member

Date Joined Jul 2009
Total Posts : 153
   Posted 12/20/2009 4:33 PM (GMT -6)   
Hi there to you all,
Well for me to see this post makes a lot of sense .......I certainly don't feel so bad now, as I've been trying to work out why I was feeling less interested for many many months.  So it could be mthx or remicade as I was until last month on both (had to come off mthx due to liver complications).  If it was mthx then hopefully for me things will improve.smilewinkgrin
Hang in there and like the others have said 'ask your doctor' I should have months ago......and maybe today when I see him will ask.
All the best.

Veteran Member

Date Joined Sep 2008
Total Posts : 1670
   Posted 12/21/2009 2:14 AM (GMT -6)   
I've just been switched onto remicade from humira and I've been on mtx for a couple of years. I feel fine, no loss at all, but I also started HRT 2 months ago so maybe that is helping me. If I start to lose it we'll know it could be the remicade!!!

But I agree, pain can be a downer, talk to your rheumy, golitho

New Member

Date Joined May 2011
Total Posts : 5
   Posted 6/6/2012 11:46 AM (GMT -6)   
I'm only 33 and my libido is gone. And i mean GONE! I'm really really concerned. I know this is a taboo subject but I'm only just rehabilitated out of a wheelchair and been on methotrexate for about over 8 months. I thought my low interest was due to pain which it was a factor. But as I'm feeling much better and would like to date and one day have children. Im starting to get really worried. I can't come off the metho cause I loose my body and on it I have zero sex drive. At a young age this is very much a problem for me. I better tell my doctor. I'm really upset. cry
This was meant to be an exciting time as its been a ruff few years losing my body to RA. (I have it in every joint). And now who's gonna want someone who can't do ......that.

New Member

Date Joined Jun 2014
Total Posts : 1
   Posted 6/17/2014 2:49 AM (GMT -6)   
I have been on Prednisolone and methotrexate for RA for 7 years and for some of this time Celacoxhib also - result = sexual disaster.
used to use Viagra and Cialis to counteract it but even they stopped working. Five months ago I went to see a consultant urologist who told me that ALL of these drugs cause the problem and the steroid shrinks your nuts (so true) I have ignored all other doctors and RA specialist and come off both. Slowly because you cannot just quit prednisolone and Mtx. Since then my condition is improving slowly and night time erections are returning. I am using Ibuprofen to cope with the RA until I prove I am capable again. I have told my RA consultant to leave me alone and he has given me 4 months to test the issue. After that we will discuss what I should be on and then it will be HONEST discussion and not the closed uninformed rubbish I was given since I got this disease.

Regular Member

Date Joined May 2013
Total Posts : 481
   Posted 6/17/2014 6:44 AM (GMT -6)   
Thanks for digging this old post up. I had no idea mtx could have an effect on libidos. I have been wondering now for months what the deal is and now I know :(

Veteran Member

Date Joined Aug 2006
Total Posts : 9607
   Posted 6/17/2014 11:24 AM (GMT -6)   
RAB, so very sorry for what you've been going through. Just remember to keep that line of communication open between you and your doctor. Maybe one of the new JAK inhibitors could help you out better, maybe get a RA magazine and look at all the newer meds that have come out.
They are even using an older approach for RA using Antibotic treatments which might help you out.
Just a side note, you commented on an older thread and some of the people from 2012 are not here anymore, so it might be good to start a newer thread and introduce yourself.
Many well wishes in your RA fight. Hope you come and post more often.
* So many dx's I could write a book* "It would be nice if we could use the edit button in real life"...

New Member

Date Joined Oct 2014
Total Posts : 1
   Posted 10/25/2014 11:17 AM (GMT -6)   
I am on 25 mg metheltrexate every week & 600 mg Remicade every 6 weeks. I have NO sex drive, what can I do?

Regular Member

Date Joined Sep 2014
Total Posts : 64
   Posted 10/25/2014 4:31 PM (GMT -6)   
I was on Remicade and Methotrexate for several years and never lost libido, I guess everyone is different.

I did however take Effexor for a bout of depression once and that stuff certainly caused a forced abstinence!
Psoriatic Arthritis - 25 years
Various bulging discs and wrist deformities
Current Rx: Otezla, Predisone, Zyban, Methadone
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