Chatted with you a bit on your other thread, sorry you are having all the side effects! Never have been on predisone, resisted that so far. So, can't help you there. But was wondering if I could ask you a question about the mtx? If you son't mind, how much do you take and how long have you been on it? I've been taking it for about almost 3 months now, and haven't noticed any hair loss, etc, as of yet. Although did ask my hairdresser to let me know if she thinks there is any changes.
I think from what others here have said, if the fatigue and other issues get too bad, your doctor can adjust the folic acid, that is supposed to help with all of that, I think.
I've never taken prednisone long-term, but my mother has. Every single time she came off it she lost her moon face pretty quickly. I know that I was on prednisone for a week. When I came down off it, I lost 8 pounds in one week (gained 6 the week I was on it). At least some of your extra weight is probably water retention--this will certainly go away quickly.
I'm curious about your mtx side effects. You mention hair loss and fatigue? Hair loss, at least, is associated with a disruption in your folic acid pathways. So, if you're taking folic acid that should help with hair loss overall. My rheumy said if I ever start getting mouth ulcers or hair loss, just increase the folic acid I'm currently taking. I only take 1mg/day, but he told me he has patients that take up to 5 mg/day. If you're not taking folic acid, you really need to call your rheumy and ask why not. If you are taking it, consider increasing the dose.