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Nana of 2
New Member

Date Joined Sep 2007
Total Posts : 10
   Posted 11/30/2007 2:47 PM (GMT -6)   
Happy Friday all:
Just got back from the Rheumy yesterday and I have a little question for you all.
I have been taking Methotrexate 8 pills every Tuesday and Plaquenil 2 pills one day, and the next day 1 pill.  There has been some improvement in my feet and knees and shoulders, but my hands had gotten worse.  All my blood tests are fine.
The Rheumy is suggesting I either change from the 8 pills of metho to 10 pills or go on the self injection needle every Tuesday.  I really don't feel good about the injection but of the two choices she seems to think the injection would be more beneficial because apparently it stays in your system longer or something.  Anyway, I would like to hear from anyone who has changed from the pills to the injection and found it beneficial or not.
Thanks for all your support and I hope you all have a great weekend.
Colleen (Nana of 2).

Veteran Member

Date Joined Dec 2005
Total Posts : 1782
   Posted 11/30/2007 11:44 PM (GMT -6)   
Hi Colleen - I did the switch from oral to injectible and it made a huge difference in how I felt. The pills made my side effects more pronounced and they didn't 'sit' well in my stomach. When I switched to the injectible, the side effects lessened (we did up my folic acid to 2 mg's from 1 mg) and I never had that funky feeling in my stomach. It seemed that I felt better faster with the injections as well.

I'm on .7 ml (equal to 17.5 mgs I believe). Personally, I'd rather do one shot than try and swallow 10 or more little pills. I'm so used to injecting myself, I don't think twice about it now. I was also on Enbrel when I switched so I was giving myself 3 shots a week! It's the first shot that's scary. After you get over that, it's a breeze.

Good luck with your decision - it's really what works best for you.

Enjoy your weekend.

Some days you're the bug, some days you're the windshield

RA, AS, intolerance/sensitivity to gluten, wheat and dairy.

Remicade every 6 weeks, Methotrexate weekly, Folic Acid daily

Nana of 2
New Member

Date Joined Sep 2007
Total Posts : 10
   Posted 12/1/2007 11:28 AM (GMT -6)   
Hi Star:
Thanks for your quick reply.  Happy to hear it helped you with the switch.  I guess you are right, the first time is the worst.  Even when I have blood taken I can't look - well I guess I will have to look or God knows where the needle will go!!!  I was reading one of your earlier posts about your doctor's name and I was laughing when you said you have to be careful not to call him Dr. Pepper (Ha Ha).  He would probably get a kick out of that though - or does he have a sense of humor?  You sure have to have one with this disease, don't you.  My Rheumy (Dr. Shat Shat - I could probably screw that name up too!!!) doesn't have one - I was a few minutes late for my appointment and she was giving me dirty looks when I went in and she said " I run a tight ship here"!!!!
I might change docs down the line.  Anyway, thanks again for your help Star.
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