Hi there. and welcome to HW. I think you'll find it a wonderful resource filled with caring people who have both personal and professional experience on these types of topics. I have RA, and recently have been dx with secondary sjogren's. My rheumatologist started me on plaquenil, but it did nothing at all for me. He added enbrel, and five months later, I started taking mtx with the enbrel. Right now, I'm taking all three drugs, but I've cut my plaquenil dose in half and will eventually phase it out altogether, as it is not necessary when you take enbrel and mtx. Interestingly, my eyes started bothering me in a major way right around the time I cut my plaquenil dose in half. Coincidence? Probably, but I'll keep an eye on it anyway (No pun intended).
In answer to your question, I don't believe that plaquenil has been associated with lymphoma, but having connective tissue disease in general, and sjogren's specifically, puts you at risk (although as you pointed out, it is rare). It is something that concerns me as well, and now I'm wondering if using a biologic (like enbrel) increases the lymphoma risk even more in someone with sjogren's? I believe there is someone else here that developed a low-grade lymphoma from taking enbrel, so perhaps they could offer more specific information.
I too suffer from Sjogrens Syndrome, had the paper test done a few years back. I'm also a long term suffer of Ankylosing Spondylitis. I beleive Sjogrens to be a by-product of my Ankylosing Spondylitis. I also suffer from chronic prosatitis & now chronic iritis. Again I believe all to do with my malfunctioning immune system.
I was also taking Remicade for around 5 years, which helped my AS, but none of the problems I have mentioned. Infact my iritis & prostatitis came about whilst on the Remicade.
I may be trying Humira in the future.
I guess all this is "in part" passed on to us. Like you, my Mom had most of my problems. She had Per. Neuopathy from her knees down so that she could not walk the last couple of years she lived. My Neuropathy developed after Shingles, which left me with PHN. about 8 months ago, developed severe pain on the opposite side, but with out breaking out. The feet were already fairly numb, but with the side pain, became so painful I could hardly sleep at night. After about 3 months, I started to improve. Surprising, the pain and numbness in both hands improved to where I just have mostly burning and itching occasionally. The feet are another stroy. I have had the nerves checked in legs and ankles- just borderline. Th onc. tell me that my NHL was caused by the IGM antibodies not fighting for me anymore. I guess you would call it a IGM deficenancy. The Rhum. had told me earlier that I had a IGA def. The Immune system breaks down. I've just turned 69 and developed most of my problems around 60. L and L's Mom