Plaquenil or Methotrexate?

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Dinglehopper1989
New Member


Date Joined Apr 2017
Total Posts : 14
   Posted 5/7/2017 5:37 PM (GMT -6)   
I have primary Sjogren's. Fatigue is my biggest problem. My joints are doing ok right now with Plaquenil, but the fatigue is really terrible. Would Methotrexate help the fatigue more? Should I switch to Methotrexate? Thank you!

Lynnwood
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Date Joined May 2005
Total Posts : 7466
   Posted 5/7/2017 8:42 PM (GMT -6)   
These meds perform in drastically different ways, they are not equal to each other.

Plaquneil is a disease inhibitor, slowing the progression of the disease. Usually this is prescribed upon initial diagnosis, and never stopped, no matter which of the other meds may be added to your treatment.

Then comes Prednisone, to help get inflammation under control.
Then comes one of the three, Imuran, Cellcept, and MTX (methotrexate) to treat disease activity.

None of these meds "treat the fatigue". What you probably have is inflammation and disease activity, which causes the fatigue. Once you treat the inflammation/disease and get it under control, the symptom of fatigue will lessen.

Meanwhile it is important to eat well, get deep restorative sleep, get some mild exercise, and avoid stress.

Only your rheumatologist knows the full picture of your symptoms and labs, along with how you have responded to treatment so far, to be able to suggest a particular medication that might be right for you.

Best wishes!
Lynnwood, Lupus & Sjogren's Moderator, Dx: 2000
DIAGNOSING LUPUS & HW's LUPUS 101
"Life is far too important to be taken seriously." - Oscar Wilde

Dinglehopper1989
New Member


Date Joined Apr 2017
Total Posts : 14
   Posted 7/28/2017 10:16 PM (GMT -6)   
Hi Lynnwood,
Plaquenil gradually became less and less affective for me over time. I recently stopped taking it because it didn't seem to be doing anything. But I started thinking, if it's a disease inhibitor, is there a chance it was still doing me good, even though I'm not feeling good? I'm wondering if I should start taking it again even though I don't notice a benefit.

Lynnwood
Forum Moderator


Date Joined May 2005
Total Posts : 7466
   Posted 7/29/2017 9:49 AM (GMT -6)   
We've had many people report that they don't think the Plaquenil is doing anything, but when they stop taking it they soon find out it was doing quite a bit behind the scenes. I would never stop taking it unless I developed side-effects.
Lynnwood, Lupus & Sjogren's Moderator, Dx: 2000
DIAGNOSING LUPUS & HW's LUPUS 101
"Life is far too important to be taken seriously." - Oscar Wilde

Dinglehopper1989
New Member


Date Joined Apr 2017
Total Posts : 14
   Posted 7/29/2017 10:48 AM (GMT -6)   
Ok, thank you!
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