Thanks Serafena: I didn't take the prescription, yet. i wanted to find out the side-effects. Also, juggling the meds. I like to make 1 change, follow it through for a couple of months, then perhaps another. That way if things get really screwed up it's easier to sort out. Right now, as I mentioned I am noticing a big improvement in my mood from the zoloft. But, I am waiting for the other shoe to drop. I noticed a bit last week, I was kind of cranky with my Dad whom I care for. It's no wonder. The other sibs have totally abandoned us and I have to care for him 24/7/365. Sometimes I get short tempered. We're also in the midst of financial troubles. My stepmother has gone to a nursing home, took all her check, left all the bills, and the bank is getting nasty.Sometimes it's hard to sort real life problems from effects of BiPolar disorder, then add a meds cocktail and one has quite a mix.