I was on Zyprexa for a while, and I broke out in hives all over my body. Thankfully they went away after I discontinued med. I tried several mood stabilizers before I found one that is working well for me so far. Right now I am on Risperdal. Everyone reacts differently to meds, I guess that is why most BP's have to try different ones until you find the one that helps the most with the least side effects.
Good luck to your husband and if it does not work, don't let him give up! Like last night, I felt so good and relaxed and I thought well that's it, I am not taking any more meds. When I woke up this morning I realized that thought was coming from my BP brain and not the voice of reason.