I have been on Depakote now for about 4 months, if not more; I cannot remember. Anyways, I have not had any side effects while taking Depakote. I didn't even get sleepy on it when I took my morning dose. The only thing that I do not like about it is that it makes me hungry a lot, almost all the time. Especially at night, so I try to eat small meals have a few mini snacks in between to help with the cravings. Other than that it has been a good Rx for me, no problems that I know of.