Keep doing what you are doing & give the new meds some time. It may take a few weeks for them to fully work properly.
You are on the right track and your wife is very lucky to have such wonderful support!
How long has she been on this new medication adjustment? It would be good to watch her and not let the depression go too long without urging her to contact her pdoc for his/her input on the matter. Just my opinion.
Wishing you both all the best!