Thomas, I've been taking zyprexa since last June. My pdoc started me on it during a particularly bad manic episode, and I responded to it well within a couple of days. Almost immediately, I was able to sleep and become less irritable. Zyprexa has really worked well with me. I take 5mg zyprexa each evening, and have not gained any weight since being on it. My pdoc also prescribed Topimax at the same time and said that it helps curve any excess hunger and prevents weight gain while on the zyprexa.
Unfortunately, there are alot of bad news stories and articles written about the side effects of zyprexa. A couple of times they have scared me and I have tried going off of it with my pdocs help, but have ended up going back on it because I just feel better and happier while on it. For me, taking zyprexa and being calm and happy is worth it. I've made peace with the medicine and am thankful that it's available to me. Hopefully, it can make you feel better, too!