Zyprexa...anyone have info?

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Peachlove
Regular Member


Date Joined Dec 2007
Total Posts : 29
   Posted 7/7/2009 8:21 PM (GMT -7)   
I was just put on Zyprexa 5mg in the morn...and then 5mg at night for 1 week then 2nd week 5mg morning and 10mg at night and if 10mgs makes me to sleepy then I can go down 5mgs and klonopin 1mg 3 times a day as needed....I just took my first 5mg pill so I am not sure what to expect....and worried at the same time. I want to feel better but I have to admit the highs and better than the lows and I don't want to be zombie'd out. Any feed back would be much appreciated....also I only weigh 108 and she said I need to be careful with my diet and calorie intake.
Peach

serafena
Veteran Member


Date Joined May 2007
Total Posts : 3715
   Posted 7/8/2009 7:59 AM (GMT -7)   
Hi Peachlove,

Zyprexa has a great reputation for evening out mood swings. It's supposed to be really effective. However it also has a bad reputation for weight gain. Soooo, yeah, be aware of that and try to moderate that. You shouldn't be zombied out, though. If you are, call the doc, because that isn't right. You'd be on the wrong dosage of something.

Hope that helps,
serafena
Serafena
Co-Moderator, Bipolar Forum
Bipolar II


Carenpolar
Veteran Member


Date Joined Mar 2007
Total Posts : 672
   Posted 7/8/2009 4:31 PM (GMT -7)   
I have taken Zyprexa 5mgs. since 2006..It works very well for me..
 
hugs, Caren

Peachlove
Regular Member


Date Joined Dec 2007
Total Posts : 29
   Posted 7/8/2009 6:31 PM (GMT -7)   
So far.....its ok....I just find that I am more tired than usual....but I am taking 5mgs at night and 5mgs in the morning......I think its that morning one.
Peach

slz727
Regular Member


Date Joined Jun 2009
Total Posts : 216
   Posted 7/8/2009 7:03 PM (GMT -7)   
Peachlove,

I am so glad you asked this question because, I was just put on this medication to day 5mg in morning and 20mg at night. I feel the same way you do about being zombied out or overly tired and I would much rather be high then low! I just took my first dose and am woried because I also just started Geodon and that is an appitite supresent and with what Serafena stated I hope that the Geodon dosen't stop the low appitite. Please let me know how you are doing and I will keep you updated on how it is working out for me.

SLZ

paktype
New Member


Date Joined Dec 2008
Total Posts : 7
   Posted 7/9/2009 4:51 AM (GMT -7)   
My wife's been on Zyprexa for many years. It does make her sleepy (very) and it does contribute to weight gain, but it does work pretty well.

BPWife
Regular Member


Date Joined Mar 2009
Total Posts : 139
   Posted 7/10/2009 7:21 AM (GMT -7)   
Peachlove,
I know that everyone responds to medications differently but I have heard more positive than negative about Zyprexa.

After trying Seroquel and Abilify, my husband was given Zyprexa and really liked it. Right now he takes it only at night and only when he needs to "take the edge off." He's also on lithium which he has (finally!) been 100% compliant with for the past 2-1/2 months. His pdoc is okay with him taking the Zyprexa occassionaly as he responds much better to the lithium to stabilize his mania. The Zyprexa helps him relax and then sleep - which as we all know is very important with BP.

I too have heard about the weight gain but as your doctor said, you just need to watch your diet. Then again, don't we all need to watch our diets? :)

Let us know how it goes.

BPWife

hopefulness
New Member


Date Joined May 2008
Total Posts : 5
   Posted 7/11/2009 2:34 AM (GMT -7)   
HI there,

Lithium can also cause considerable weight gain in some and it is not necessarily diet related, it is to do with fluid retention casued by Lithium, so you have double whammy taking Zyprexa too , but if it helps to stabilize the mood successfully and allows someone to feel happy and normal or more level and actually functional then its worth the extra wieght gain, though not desirable. No point being thin and miserable or seriously depressed or manic and destroying your life or making everyone else deeply unhappy with very unplesant dysphoric manif or hypomanic aggressive/ abusive or reckless behaviours or ruining relationships. Its a compromise. Regular exercise can certainly help to minimise some of the additional weight gained by the Lithium and Zyprexa and careful attention to dietary intake. IT shard work but worth the effort. Good luck. DElighted the combination of meds is working for him at long last.

I wish my partner would consider trying Lithium again. He was taken off it years ago as it is not always considered so helpful in frequent rapid cycling, apparently, though some more recent research disputes tese findingss now and says it can be just as effective but probably needs a farly high does or to be combined with another stabilizer such as Depakote or Sodium Valproate, and possibly even the addition of an atypical antipsychotic. I sincerely wish he could find something that would work as this illness is wrecking our relationship and happiness and getting in the way of any normal life together.He was transferred onto DEpakote but on far too low a dosage. Since then it has benn increased from 750mg Depakote to 2000mg Depakote, but he still sufferred very much with depressions. Every time he was given any type of antidepressant with it, he rapidlu became very hypomanic, verging on manic and these episodes lasted fir many many months, sometime 3-4. Once off the anti Ds he was no as hpomnic, but became very depressed with shorrter periods of breakthrough hypomanias, and that woulfd be followed by wekks of Mixed moods, in which although he had an underrlying depressive mood, the hypomanic mix tended to predominate and was most unplesant. For a few months he was also given Seroquel which apperaed to hep restore more rational thinking and reduce hostility but it was never given apparently in a sufficient dosage ( Only 150mg- 300mg maximum ) to be in any effective at aborting an existing hypomanic epiosde or at preventing a worse hypomanic episode eventually, during wich he stopped it al together and never resumed it until this year whe I encouraged him to take it again as he had so much agitation and had just come out ofa 5 month mania/ hypomania which was so destructive and distressing, and I believe was triggered by the addition of Lamotrigine. IN the past 3 years it appears all of his highs have been brought on by reintroducing lamotrigine or after every increase above 50mg. WE have had the worst 3 years of cycling with very long epiosdes of maainly hypomania with shorter months of Depression, when he usully agrees to renain off Lamotrigine as at that point when he comes back down he realizes the Lamotrigine has beencausing him to temain far too high andhe is highly aggressive, dismissive, severs our relationship, threatend all manner of poilce interventions when I contact his mental health team or family to let them know he is unwell, as he believes himself to be very well when high but clearly by his activities is far from that. I KNowe I have to inform them but this angers him even more, though I would point out he uses this as as justification or to rational his aggressive behviour. It is not infact the cause of his anger, because his hostility started out of the blue without us falling out and preceded me communicating with anyone about his need for help. He has no insight right from the start of a hypomanic epiosde. His judgement is lost very early on and remains lost throught the whole episode.

He is hypersexual, contacting people on inappropriae websites, indiscriminately socializing, aleays wanting to take off somewhere abroad or staright up to London, starts drinking more, taking lots of diet coke loaded on caffeine, starting all sorts of risky financial and business ventures though has no money to fund them.

The problem is when he sees his mental health team ,if they can engage with him ,which is difficult when he is high as he believes there is no problem and wil not turn up to appointments, they do not always spot his symptoms as he can be so articulate and plausible about his poerceived wellness nad ofcourse he does not describe anything of the activities I know he si doing oitside of thr consultation room, and he is not hostile to them as he is to me. It is very hard to get them to cahnge anything and they keep recommending Lamotrigine, so he says, though as I am not there I do not entirely believe this. I think it is he who wants to continue it. He will not allow me to come to the consuktaions. He used to in the past but never whe he is high, as he opposes my observations and knows I am likely to suggest he is taken off Anti Depressants in the past, as they always do whe high , or lamotrtigine in past 3 years in place of them which I can see quite clearly make him v ery aggressively high indeed.

I am at my wits end. He has just deserted me agin as soon as he became hypomanic, he was off and I was pushed away in very intimidating terms, though we had no fall out or uoset at al. He just seemed to change mood overnight whilst on his own for about 2 days but had not been high when he left my house to attend to something at his flat. I subsequently discovered about 10 days later as I suspected that he had recommenced lamotrigine once on his own, and Probably disbelieved it would make him high and tha he could hide it from me. I do understand he wants to take it ina desperate attempt to treat his depression swhich are awaful and I have rerpaetedly asked his team fir reassessment of his meds and to be offerred a suitabel alternative to lamotrinie to treat boith phases of the illness. lamotrigine is only effective as a fast elevating so called stabilizer to treat the depressive ohases of the illness, and it does wotk quickly which is why many people love it, however ,It is unlike all the other anticonvulsnat stabilizers in so much as it offers no protection agianst the manic phases, and I have confirmed this with the psychpharmacologist. IN effect it is more like an anti depressant, and is not a true stabilizer like Lithium and valoproate, and I believe ot should not be heralded as the new wonder drug for Bipolar. I would not touch Lamotrigine with a barge pole ! I has caused the worst and the longest and most destructive highs he has ever had, as bad as any antidepressant switching into mania or hypomania, but much longer epiosdes of damaging highky irritable, risky and agressive hostile hypomania with a total and unshakeable loss of insight.

hopefulness
New Member


Date Joined May 2008
Total Posts : 5
   Posted 7/11/2009 3:34 AM (GMT -7)   
Does anyone have any ideas re above or similar experience with lamotrigine triggering really long hypomanic eisodes. I think that the beneficail effects of lamotrigine are grossly over estimated due to the fact that a very high proportion of people experiencing Bipolar Disorder do not recognise or report their hugh symptoms or see the damage and distress it it causing to others as they wnat to maintin that high feeling, so I believe the research on lamotrigine is completely skewed by this failure to iudentify or report hypomanic effecst of this drugs. Pharamaceutical companies are makinga apacket out if it, far more than Lithium and it is being heralded as the wonder drug fir rapid cycling. As it offers absolutely no protection against the manic of hypomanic phases how can this be. It may stop people cycling down into depression, but it certainly prolongs hypomania whci codem psychiatrists come to believe is the normal character of the perso as it can last so long, but clients usually conceal or are un aware of all the other inappropriate stuff they are doing outside of the consultation room, so may come across as well when infact they are hypomanic to all those who actually know them well. A half an Hour consultaion can never give a true picture of hypomnia. Obviously Depression and Acute mania are harder to concela and easier to identify by the psychiatrist at least, if not the client, but moderate levels of hypomania which can be so dmaging just slip through the net and are grossly undertreated. Anynone lese find the same or have any suggestions of how to get the ental health teams oto see this. I have had to resort to sending 3rd party accounts or emails to show exactly what my partne is doing as he will never relay this to them and they are beieng mislead by his plausibility and confidence and articulacy during hypomanic phases. He can talk the talk , so never gets the adjustments of treatment he so needs.

serafena
Veteran Member


Date Joined May 2007
Total Posts : 3715
   Posted 7/11/2009 4:45 PM (GMT -7)   
Hopefulness,

I'm sorry to hear your partner's illness has taken over his life so completely. You are going through the hard part of being with a poorly maintaining bipolar partner. It's devastating. But in the end, it's important to remember that it's up to him to make the good choices. You can beg and plead and facilitate and try to help, but if he won't do the work, then there's little you can do. You can't feel guilty or take responsibility for his choices. He may be ill, but he still has them. We all do.

Try to remember that the medications affect everyone differently. I've been on lamotrigne for 6 years with nothing like the reactions your partner has had. It's been the drug that has made all the difference for me. BUT I have severely depressive symptoms with intermittent hypomanias. So it depends entirely on the person, not the drug. Maybe your partner needs a fresh outlook on his meds. Has he been with the same psych group for a number of years? Maybe it's time to try someone new, see if they have something fresh to say about the meds. There are so many options out there, there's no reason to stay with the same 4 or 5 drugs if they aren't working.

As to getting him to appointments, well there's the rub, eh? He's got to decide to do that on his own. In the end, you've got to make it clear to him that staying healthy is crucial to your relationship. Are you prepared to do that?

Best wishes,
serafena
Serafena
Co-Moderator, Bipolar Forum
Bipolar II

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