I hope Saphris works out for you. I did not have a good experience with it, but I have had bad reactions to alot of meds. It made me feel great for about a week or two, then I got manic, very manic, worse than when I was not taking any meds at all. So PDoc increased dose and it sent me rapid cycling, had to stop it. I did enjoy the fact that side effects were pretty minimal and I hope it works out for you. I am bipolar 1, so I have hypomania/mania issues more than depression.