After months of begging my doctor to ween me off of Seroquel I took things into my own hands. I started upping my dose of Lithium and slowly lowering my Seroquel. I am proud to say I have reduced from 600mg to 400mg all by myself. I feel so much better now even with this small change. Seroquel just made me drag all the time even though i was taking the XR tablets. I've been on it for 5 years and counting. I miss my mania's a little bit. I was not the fun person I used to be and became a hermit staying home all of the time. The other thing was the cost of Seroquel....very expensive with no insurance. Anyways, just wanted to share. Hope all is well with everyone!