I began on Celexa 20 mg and was bumped down to 10mg as it made me irritable. That said, I am also on Seroquel and Lithium as mood stabilizers-I would never be on Celexa without them, as it would cause a cycle into mania/hypomania. I love it-it keeps the depresssion away-that said, the Seroquel also seems to help in that dept. , although not proven to my knowledge. Everyone is different Ashley, and you may love it or hate it based on your chemistry. Best thing to do is try it and see your Doc if you go downhill -I know, it is such a guinea pig science. But when it works, it is beautiful! I hope it works for you as it has for me and your Grandma!