Ellie my pdoc and I are talking about lamictal and I am game. The rash is rare and if dosed slowly, moreso. If you do get the rash, I have been told by pdoc that it is unmistakable and you just stop as prescribed by doc before treatment. I have seen patients on it and no rash. Seroquel works wonder on my rage/irritability, all of the feelings you desribe, just hate the weight gain-maybe it could work for you? I know that you have a stressful life, which doesn't help on top of the "mania" irritability. Plus I sleep like a baby so that I get the sleep I need to decrease more irritability from insomnia.