Hi, I'm normally on the Ulcerative Colitis board, but I saw you mention Lamictal, so I thought I would respond. I'm not on it anymore, but the effects of it were ok for me. The main reason it helped with me with the depression/anxiety is because it kind of 'blurred' my brain. That's about the only way to describe it. It slowed my thinking down to the point that I wasn't worrying/being depressed about anything. It didn't make me tired either. The reason I stopped it is because it gave me a terrible memory. I couldn't remember things that my wife would tell me 5 min. ago. And this wasn't just every now and then, it was all the time, day and night. So I guess if someone really needed something, this would work, but with that side effect I had to stop. As far as initial side effects, I had absolutely none. I was taking 25mg a day, then worked up to I believe 200mg. I did develop a rash at first, but after seeing a dermatologist, I found out it was just contact dermatitis, which had nothing to do with the Lamictal. So I continued taking it until my memory loss got out of control. Hope this information helps and I hope the Lamictal works for you.